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Evidence found and GRADE certainty

2,413 questions · 2,602 findings · 93 reviews · Oral Health

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No studies found 452 · 17.4%GRADE not reported 1,582 · 60.8%Very low 392 · 15.1%Low 122 · 4.7%Moderate 53 · 2%High 1 · 0%

Leukotriene receptor antagonist vs placebo

Time to resolution of first ulcer (days) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Montelukast (leukotriene receptor antagonist; 10 mg daily for 1… led to lower time to resolution of first ulcer (days) compared with placebo; GRADE not reported.

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Reduction in number of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

LongoVital (herbal component alone) vs placebo

Mean size of ulcers · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

LongoVital (herbal component alone) showed no clear difference in mean size of ulcers compared with placebo; GRADE not reported.

1 finding from 1 review

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Eating healthy snacks at least twice per day · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Titanium framework FDP vs High-gold content alloy framework FDP

Unacceptable restoration (poor marginal integrity / restoration removal) · Partially edentulous patients receiving tooth-supported FDPs

Titanium framework FDP led to higher unacceptable restoration (poor marginal integrity / restoration… compared with high-gold content alloy framework FDP; GRADE not reported.

1 finding from 1 review

Nanocrystalline hydroxyapatite (Ostim) vs Bovine-derived xenograft (Bio-Oss) plus resorbable barrier

Change in probing attachment level (PAL) · People with at least one dental implant affected by perimplantitis

Nanocrystalline hydroxyapatite (Ostim) led to lower change in probing attachment level (PAL) compared with bovine-derived xenograft (Bio-Oss) plus resorbable barrier; GRADE not reported.

1 finding from 1 review

Xenogeneic collagen matrix (porcine; Mucograft) vs Connective tissue autograft (palate)

Recession (aesthetics) · Patients with implant-supported prostheses and <=1 mm keratinised mucosa

Xenogeneic collagen matrix (porcine; Mucograft) showed no clear difference in recession (aesthetics) compared with connective tissue autograft (palate); GRADE not reported.

1 finding from 1 review

Reassurance / behavioral management (control of contributory factors)

Outcome not reported · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

The review found no eligible studies for this question.

1 finding from 1 review

1% pimecrolimus cream vs Placebo (vehicle cream)

Physician Global Assessment (weighted sums of ulceration, erythema, reticulation, mm2) · People with erosive oral lichen planus

1% pimecrolimus cream showed no clear difference in physician Global Assessment (weighted sums of ulceration, erythema,… compared with placebo (vehicle cream); GRADE not reported.

1 finding from 1 review

Any topical or systemic intervention vs Placebo, no treatment, or another intervention

Outcome not reported · People with erosive oesophageal lichen planus

The review found no eligible studies for this question.

1 finding from 1 review

Pentoxifylline vs placebo

Pain, number of ulcers, ulcer-free days and ulcer size · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
    60 days (plus 60-day follow-up)
    A single trial at high risk of bias compared pentoxifylline 400 mg three times daily (n=14) with placebo (n=12). No statistically significant differences were reported for pain, number of ulcers and ulcer-free days at…
    1 study · 26 participants
    GRADE not reported