Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,121 questions · 2,186 findings · 242 reviews

No studies found 493 · 22.6%GRADE not reported 158 · 7.2%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.7%High 97 · 4.4%

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Early neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Late neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection

The review found no eligible studies for this question.

1 finding from 1 review

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with possible serious bacterial infection

Comparison 2: 2 days oral amoxicillin + injectable gentamicin… showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Neonatal mortality · neonates with fast breathing alone

Comparison 2: 7 days oral amoxicillin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Treatment failure · neonates with fast breathing alone

Comparison 2: 7 days oral amoxicillin showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐positive and gram‐negative coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes abdominal surgical site infection compared with gram‐positive and gram‐negative coverage (very low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐positive and gram‐negative coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes intra‐abdominal infection compared with gram‐positive and gram‐negative coverage (very low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐negative and anaerobic coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes abdominal surgical site infection compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

Anaerobic coverage only vs gram‐negative and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes intra‐abdominal infection compared with gram‐negative and anaerobic coverage (very low certainty).

1 finding from 1 review

Gram‐negative and anaerobic coverage vs gram‐positive, gram‐negative, and anaerobic coverage

Abdominal surgical site infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether gram‐negative and anaerobic coverage changes abdominal surgical site infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review