What do systematic reviews say?

FAE vs placebo

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low

FAE vs placebo

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 175 participants
  Low

FAE vs placebo

FAE probably leads to higher common nuisance AEs (not leading to treatment discontinuation) compared with placebo (moderate certainty).

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  RR 4.72 [2.45, 9.08]
  1 study · 99 participants
  Moderate

FAE vs placebo

FAE may leads to higher PASI 50 compared with placebo (low certainty).

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  RR 4.55 [2.8, 7.4]
  2 studies · 247 participants
  Low

FAE vs placebo

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 247 participants
  Low

FAE vs placebo

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

FAE vs MTX

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 51 participants
  Very low

FAE vs MTX

It is very uncertain whether FAE changes AEs leading to treatment discontinuation compared with MTX (very low certainty).

• Oral fumaric acid esters for psoriasis 2015 · Cochrane Headline outcomes only
  RR 0.19 [0.02, 1.53]
  1 study · 51 participants
  Very low

Cetirizine 10 to 20 mg vs placebo

Cetirizine 10 to 20 mg may leads to higher complete suppression of urticaria Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 2.72 [1.51, 4.91]
  2 studies · 178 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 100 participants
  Low

Rupatadine 10 to 20 mg vs placebo

Rupatadine 10 to 20 mg may leads to higher good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.35 [1.03, 1.77]
  1 study · 245 participants
  Low

Loratadine 10 mg vs placebo

Loratadine 10 mg showed no clear difference in good or excellent response Global assessment of symptom scores compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.86 [0.91, 3.79]
  2 studies · 124 participants
  Low

Loratadine 10 mg vs cetirizine (antihistamine)

Loratadine 10 mg showed no clear difference in complete cessation of urticaria Global assessment of symptom scores compared with cetirizine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.05 [0.76, 1.43]
  2 studies · 103 participants
  Low

Loratadine 10 mg vs desloratadine 5 mg

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.91 [0.78, 1.06]
  2 studies · 369 participants
  Low

Loratadine 10 mg vs desloratadine 5 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.64, 1.71]
  3 studies · 410 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

It is very uncertain whether loratadine 10 mg changes complete cessation of urticaria: intermediate‐term duration of… compared with mizolastine 10 mg (very low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.86 [0.64, 1.16]
  3 studies · 316 participants
  Very low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.88 [0.55, 1.42]
  3 studies · 314 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.38 [0.04, 3.6]
  2 studies · 267 participants
  Low

Cetirizine 10 to 20 mg vs placebo

Cetirizine 10 to 20 mg showed no clear difference in adverse events leading to withdrawal compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 3 [0.68, 13.22]
  3 studies · 389 participants
  Low