Findings

What do systematic reviews say?

2,908 questions · 3,101 findings · 509 reviews

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No studies found 571 · 18.4%GRADE not reported 358 · 11.5%Very low 723 · 23.3%Low 854 · 27.5%Moderate 489 · 15.8%High 106 · 3.4%

Prostacyclin vs control

Six‐minute walk distance · pulmonary arterial hypertension

1 finding from 1 review

Prostacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 2283 participants
Low

Prostacyclin vs control

All‐cause mortality · pulmonary arterial hypertension

Prostacyclin probably leads to lower mortality compared with control (moderate certainty).

1 finding from 1 review

Prostacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes only
OR 0.6 [0.38, 0.94]
15 studies · 2554 participants
Moderate

Prostacyclin vs control

Dyspnea · pulmonary arterial hypertension

1 finding from 1 review

Prostacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1521 participants
Low

Prostacyclin vs control

Quality of life · pulmonary arterial hypertension

1 finding from 1 review

Prostacyclin for pulmonary arterial hypertension 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 271 participants
Moderate

Glutaraldehyde + zinc oxide and eugenol (ZOE) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + zinc oxide and eugenol (ZOE) showed no clear difference in clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
3 months
RR 0.46 [0.04, 4.74]
1 study · 48 participants
GRADE not reported

Metapex (calcium hydroxide/iodoform) vs Endoflas chlorophenol free (Endoflas-CF)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with endoflas chlorophenol free (Endoflas-CF); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 1.33 [0.35, 5.03]
1 study · 32 participants
GRADE not reported

Low-level laser therapy (LLLT) + calcium hydroxide vs Formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Low-level laser therapy (LLLT) + calcium hydroxide showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 7.00 [0.39, 124.83]
1 study · 30 participants
GRADE not reported

Biodentine vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Biodentine showed no clear difference in clinical failure compared with calcium hydroxide (CH); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
RR 0.33 [0.01, 7.72]
1 study · 62 participants
GRADE not reported

Low‐level laser therapy vs Formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
No clinical failure in any participant (Fernandes 2015); not estimable
1 study · 30 participants
GRADE not reported

Calcium hydroxide (CH) vs Formocresol (FC)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Calcium hydroxide (CH) probably leads to higher radiological failure compared with formocresol (FC) (moderate certainty).

2 findings from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.86 [1.42, 2.44]
6 studies · 332 participants
Moderate
Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 3.11 [1.61, 6.02]
1 study · 120 participants
Low

Mineral trioxide aggregate (MTA) vs Calcium hydroxide (CH)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Mineral trioxide aggregate (MTA) may leads to lower radiological failure compared with calcium hydroxide (CH) (low certainty).

2 findings from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 0.12 [0.04, 0.36]
4 studies · 150 participants
Low
Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
up to 24 months
No radiological failure in any participant; not estimable
1 study · 50 participants
GRADE not reported

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Zinc oxide and eugenol (ZOE) pulpectomy

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate/MTA pulpotomy showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
18 months
RR 2.16 [0.23, 20.35]
1 study · 172 participants
GRADE not reported

Diode laser vs electrosurgery

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether diode laser changes clinical failure compared with electrosurgery (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 months
RR 0.20 [0.01, 3.70]
2 studies · 50 participants
Very low

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Mineral trioxide aggregate (MTA)

Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
mean 22 months
Assessed pain, soft tissue pathology, mobility, radiolucency, root resorption, pulp canal obliteration (Doyle 2010); no clinical/radiological failure outcome; no significant differences
1 study · 130 participants
GRADE not reported

Ferric sulphate (FS) vs Zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate (FS) showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 0.60 [0.26, 1.40]
1 study · 50 participants
GRADE not reported

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Calcium hydroxide (CH)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 and 24 months
RR 3.00 [0.13, 69.52]
1 study · 40 participants
Very low

Glutaraldehyde + calcium hydroxide (CH) vs Glutaraldehyde + zinc oxide and eugenol (ZOE)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + calcium hydroxide (CH) showed no clear difference in radiological failure compared with glutaraldehyde + zinc oxide and eugenol (ZOE); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
12 months
RR 1.11 [0.46, 2.67]
1 study · 61 participants
GRADE not reported

Glutaraldehyde + calcium hydroxide (CH) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + calcium hydroxide (CH) showed no clear difference in clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
3 months
RR 1.10 [0.17, 7.10]
1 study · 44 participants
GRADE not reported

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
24 months
RR 7.00 [0.38, 127.33]
1 study · 40 participants
Very low

Endoflas chlorophenol free (Endoflas-CF) vs Zinc oxide and propolis (ZOP)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

1 finding from 1 review

Pulp treatment for extensive decay in primary teeth 2018 · Cochrane All outcomes
6 and 12 months
Radiological failure (pathologic radiolucency); no significant difference
1 study
GRADE not reported