Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,413 questions · 2,602 findings · 93 reviews · Oral Health

No studies found 452 · 17.4%GRADE not reported 1,582 · 60.8%Very low 392 · 15.1%Low 122 · 4.7%Moderate 53 · 2%High 1 · 0%

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Mean pain score and mean ulcer size · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Er:YAG laser surface debridement before bone augmentation vs Plastic curettes plus saline solution before bone augmentation

Complications and side effects · People with at least one dental implant affected by perimplantitis

Er:YAG laser surface debridement before bone augmentation led to lower complications and side effects compared with plastic curettes plus saline solution before bone augmentation; GRADE not reported.

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Pain on palpation of the affected/contralateral TMJ and masticatory muscles · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate led to lower pain on palpation of the affected/contralateral TMJ and masticatory… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review
  • Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
    14 days to 6 months
    Pain on palpation of the affected and contralateral TMJ and masticatory muscles presented similar frequencies regardless of the time (Analyses 1.4-1.12); no statistically significant differences reported. Point…
    1 study · 40 participants
    GRADE not reported

Xenogeneic collagen matrix (porcine; Mucograft) vs Connective tissue autograft (palate)

Keratinised mucosa height change · Patients with implant-supported prostheses and <=1 mm keratinised mucosa

Xenogeneic collagen matrix (porcine; Mucograft) showed no clear difference in keratinised mucosa height change compared with connective tissue autograft (palate); GRADE not reported.

1 finding from 1 review

Clofazimine (100 mg daily for 30 days, then 100 mg every other day) vs placebo

Complete remission (no further aphthous episodes to 6 months) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • One trial at high risk of bias compared clofazimine (n=23) with placebo (n=20). The number of individuals in the clofazimine group who had no further aphthous episodes from beginning treatment until completion at 6…
    1 study · 43 participants
    GRADE not reported

Radix tripterygium hypoglaucum tablet (THT) vs Tripterygium glucosides tablet (TGT)

Physician Global Assessment (cure of erosive lesions, remarkably effective) · People with erosive oral lichen planus

Radix tripterygium hypoglaucum tablet (THT) showed no clear difference in physician Global Assessment (cure of erosive lesions, remarkably… compared with tripterygium glucosides tablet (TGT); GRADE not reported.

2 findings from 1 review

LongoVital (herbal component alone) vs placebo

Number of days of pain (monthly average) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

LongoVital (herbal component alone) showed no clear difference in number of days of pain (monthly average) compared with placebo; GRADE not reported.

1 finding from 1 review

Beclometasone dipropionate (systemic corticosteroid) vs Placebo or no treatment

Outcome not reported · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

The review found no eligible studies for this question.

1 finding from 1 review

Intra-articular injection of sodium hyaluronate vs corticosteroid injection

Extent of mandibular movement (maximum jaw opening, lateral and contralateral movement, jaw protrusion) · Adults (>18 years) with temporomandibular joint osteoarthritis (TMJ OA) diagnosed by RDC/TMD or compatible criteria

Intra-articular injection of sodium hyaluronate showed no clear difference in extent of mandibular movement (maximum jaw opening, lateral and… compared with intra-articular injection of corticosteroids (betamethasone); GRADE not reported.

1 finding from 1 review
  • Interventions for managing temporomandibular joint osteoarthritis 2012 · Cochrane All outcomes
    14 days to 6 months
    None of the mean differences between interventions for the measures of jaw movements (maximum jaw opening, lateral movement to affected side, contralateral movement, jaw protrusion; Analyses 1.16-1.27) showed…
    1 study · 40 participants
    GRADE not reported

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo

'No ulcer' status during last 2 months of treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Vitamin B12 (sublingual, 1000 mcg daily for 6 months) led to higher 'No ulcer' status during last 2 months of treatment compared with placebo; GRADE not reported.

1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Number of ulcers at end of 90-day treatment · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in number of ulcers at end of 90-day treatment compared with placebo; GRADE not reported.

1 finding from 1 review

Colchicine (0.5 mg three times per day) vs Clofazimine (100 mg daily for 30 days, then 100 mg every other day)

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • Clofazimine was associated with an increase in cutaneous adverse effects (Fisher's exact test P=0.015), easily controlled; there was a greater percentage of treatment interruptions in the colchicine group due to…
    1 study · 46 participants
    GRADE not reported

Perilla cooking oil vs Soybean cooking oil

Time to ulcer closure ‐ not reported · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Perilla cooking oil showed no clear difference in average number of days for resolution of ulcers compared with soybean cooking oil; GRADE not reported.

1 finding from 1 review