Intervention not reported
TIPS(3 RCTs; 189 participants) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention showed no clear difference in TIPS(3 RCTs; 189 participants) (low certainty).
1 finding from 1 review
HR 0.94 [0.56, 1.59]
Studies not reported
Low
Intervention not reported
Beta‐blockers plus Nitrates(No direct RCT) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention showed no clear difference in beta‐blockers plus Nitrates(No direct RCT) (low certainty).
1 finding from 1 review
HR 0.91 [0.53, 1.58]
Studies not reported
Low
Intervention not reported
Portocaval shunt(2 RCTs; 100 participants) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention showed no clear difference in portocaval shunt(2 RCTs; 100 participants) (low certainty).
1 finding from 1 review
HR 1.21 [0.68, 2.15]
Studies not reported
Low
Mortality (at the end of · adults receiving EN via nasogastric or gastrostomy tube
It is very uncertain whether higher threshold (500 mL per six hours or greater) changes mortality (at the end of compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).
1 finding from 1 review
Pneumonia · adults receiving EN via nasogastric or gastrostomy tube
It is very uncertain whether higher threshold (500 mL per six hours or greater) changes pneumonia (until discontinued or up to 28 days) compared with lower threshold (less than 500 mL per six hours) at time of aspiration (very low certainty).
1 finding from 1 review
Length of hospital stay · adults receiving EN via nasogastric or gastrostomy tube
1 finding from 1 review
Intervention not reported
All‐cause mortality · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
The intervention showed no clear difference in all‐cause mortality (low certainty).
1 finding from 1 review
Intervention not reported
Relapsec · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
The intervention probably leads to higher relapsec (moderate certainty).
1 finding from 1 review
Intervention not reported
Serious adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
It is very uncertain whether the intervention changes serious adverse events (very low certainty).
1 finding from 1 review
Intervention not reported
Adverse events · ≥ 15‐year‐old people with late second stage human African gambiense trypanosomiasis (trypanosomes in blood or nymph node fluid and WBC >…
The intervention showed no clear difference in adverse events (moderate certainty).
1 finding from 1 review
Complete cure, at least 3 months after the end of treatment · People with American cutaneous and mucocutaneous leishmaniasis
Meglumine antimoniate (IMMA) (20 mg/kg/d for 20 days) showed no clear difference in complete cure, at least 3 months after the end of treatment compared with placebo (3 tablets/4 times a day (moderate certainty).
1 finding from 1 review
Complete cure, at least 3 months after the end of treatment · People with American cutaneous and mucocutaneous leishmaniasis
Azithromycin (500 mg 20 ‐ 28 days) probably leads to lower complete cure, at least 3 months after the end of treatment compared with meglumine antimoniate (15 ‐ 20 mg/kg/d (moderate certainty).
1 finding from 1 review
Adverse effects · People with American cutaneous and mucocutaneous leishmaniasis
1 finding from 1 review
Recurrence ‐ not measured · People with American cutaneous and mucocutaneous leishmaniasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Complete cure, at least 3 months after the end of treatment · People with American cutaneous leishmaniasis
Topical imiquimod 5% (3 times/week) + meglumine antimoniate (IVMA)… showed no clear difference in complete cure, at least 3 months after the end of treatment compared with placebo + IVMA (moderate certainty).
1 finding from 1 review
Adverse effects (number of participants who had the event) · People with American cutaneous leishmaniasis
1 finding from 1 review
Recurrence ‐ not measured · People with American cutaneous leishmaniasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Complete cure, at least 3 months after the end of treatment · People with American cutaneous leishmaniasis
Thermotherapy one session (at 50 ºC for 30 seconds) leads to lower complete cure, at least 3 months after the end of treatment compared with meglumine antimoniate (20 mg Sb5/kg/day (high certainty).
1 finding from 1 review
Adverse effects · People with American cutaneous leishmaniasis
1 finding from 1 review
Recurrence ‐ not measured · People with American cutaneous leishmaniasis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found