Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,678 questions · 4,859 findings · 283 reviews

No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Phenobarbital vs levetiracetam

Proportion of infants who develop epilepsy post‐discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop epilepsy post discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs phenytoin

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after the maximal… compared with phenytoin (very low certainty).

1 finding from 1 review

Phenobarbital vs phenytoin

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

Summary of findings table ‐ Phenobarbital may leads to higher proportion of infants who achieve seizure control after first… compared with phenytoin (low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital probably leads to higher proportion of infants who achieve seizure control after the maximal… compared with levetiracetam (moderate certainty).

1 finding from 1 review

Phenobarbital vs phenytoin

Mortality before hospital discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with phenytoin (very low certainty).

1 finding from 1 review

Phenobarbital vs phenytoin

Need for mechanical ventilation · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes requirement of mechanical ventilation compared with phenytoin (very low certainty).

1 finding from 1 review

Phenobarbital vs phenytoin

Proportion of infants who develop sedation or drowsiness · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with phenytoin (very low certainty).

1 finding from 1 review

Phenobarbital vs lorazepam

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who achieve seizure control after the first… compared with lorazepam (very low certainty).

1 finding from 1 review

Phenobarbital vs lorazepam

Mortality before hospital discharge · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with lorazepam (very low certainty).

1 finding from 1 review

Phenobarbital vs lorazepam

Proportion of infants who develop sedation or drowsiness · neonates with clinically diagnosed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with lorazepam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes mortality before hospital discharge compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Need for mechanical ventilation · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes requirement of mechanical ventilation compared with levetiracetam (very low certainty).

1 finding from 1 review

Phenobarbital vs levetiracetam

Proportion of infants who develop sedation or drowsiness · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital changes proportion of infants who develop sedation or drowsiness compared with levetiracetam (very low certainty).

1 finding from 1 review