Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Bevacizumab plus chemotherapy vs chemotherapy alone

Specific adverse events: serious thromboembolic events · women with persistent, recurrent, or metastatic cervical cancer

Bevacizumab plus chemotherapy probably leads to higher specific adverse events: serious thromboembolic events compared with chemotherapy (moderate certainty).

1 finding from 1 review

Bevacizumab plus chemotherapy vs chemotherapy alone

Adverse events: hypertension · women with persistent, recurrent, or metastatic cervical cancer

Bevacizumab plus chemotherapy probably leads to higher specific adverse events: hypertension compared with chemotherapy (moderate certainty).

1 finding from 1 review

Cediranib plus chemotherapy vs placebo plus chemotherapy

Specific adverse events: gastrointestinal perforations or fistulae · women with persistent, recurrent, or metastatic cervical cancer

It is very uncertain whether cediranib plus chemotherapy changes specific adverse events: gastrointestinal perforations or fistulae compared with placebo plus chemotherapy (very low certainty).

1 finding from 1 review

Postsurgical medical therapy vs Placebo or no active treatment

Disease recurrence ≤ 12 months (EEC stage) · women having endometriosis surgery

It is very uncertain whether postsurgical medical therapy changes disease recurrence ≤ 12 months (EEC stage) compared with placebo or no medical therapy (very low certainty).

1 finding from 1 review

Presurgical medical therapy vs postsurgical medical therapy

Pain recurrence (dichotomous) Pain recurrence ≤ 12 months · women having endometriosis surgery

Presurgical medical therapy showed no clear difference in pain recurrence (dichotomous) Pain recurrence ≤ 12 months compared with postsurgical medical therapy (low certainty).

1 finding from 1 review