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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

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No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

CRISIS INTERVENTION vs usual care

Burden on family Numbers of families stating that overall burden is great · patients with people with severe mental illnesses

CRISIS INTERVENTION may leads to lower burden on family Numbers of families stating that overall burden is… compared with STANDARD CARE (low certainty).

1 finding from 1 review

CRISIS INTERVENTION vs usual care

Hospital use Repeat admissions excluding index admission · patients with people with severe mental illnesses

CRISIS INTERVENTION showed no clear difference in hospital use Repeat admissions excluding index admission compared with STANDARD CARE (high certainty).

1 finding from 1 review

PERPHENAZINE vs placebo

Global state: Change over time ‐ no better or deterioration ‐ short term clinically defined · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes global state: Change over time ‐ no better or deterioration ‐ short… compared with PLACEBO (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes adverse events: extrapyramidal adverse effects dystonia ‐ short term compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Other adverse events: any serious adverse event ‐ short and long term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes other adverse events: any serious adverse event ‐ short and long term compared with ANY ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

PERPHENAZINE vs antipsychotics

Service use and hospitalisation: admission ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

PERPHENAZINE vs placebo

Relapse · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes mental state: Relapse ‐ short term clinical diagnosis compared with PLACEBO (very low certainty).

1 finding from 1 review

PERPHENAZINE vs placebo

Adverse events: death ‐ not reported · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

PERPHENAZINE vs placebo

Adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term · patients with schizophrenia

It is very uncertain whether PERPHENAZINE changes adverse events: extrapyramidal adverse effects ‐ dystonia ‐ short term compared with PLACEBO (very low certainty).

1 finding from 1 review