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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
793 questions in 32 reviews · Periodontology
current versionsNo studies 148 · 18.7%Ungraded 429 · 54.1%Very low 137 · 17.3%Low 53 · 6.7%Moderate 14 · 1.8%High 12 · 1.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Doxycycline + SRP vs Metronidazole + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.12 [-0.72, 0.49] | 2 studies · 49 participants | Ungraded |
Clindamycin + SRP vs SRP Antimicrobial resistance · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Doxycycline + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Doxycycline + SRP vs SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.15 [-0.53, 0.83] | 2 studies · 43 participants | Ungraded |
Doxycycline + SRP vs SRP Probing pocket depth · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.43 [-0.88, 0.01] | 3 studies · 65 participants | Ungraded |
Azithromycin + SRP vs SRP Antimicrobial resistance · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Amoxicillin + metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.04 [-0.35, 0.26] | 6 studies · 215 participants | Ungraded |
Metronidazole + SRP vs SRP Probing pocket depth · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.59 [-0.95, -0.23] | 4 studies · 94 participants | Ungraded |
Doxycycline + SRP vs SRP Antimicrobial resistance · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Doxycycline + SRP vs SRP Adverse events · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included study has not reported adverse events | NR | No studies |
Clindamycin + SRP vs Doxycycline + SRP Patient-reported quality of life changes · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Metronidazole + SRP vs Amoxicillin + metronidazole + SRP Probing pocket depth · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.26 [-0.83, 0.31] | 1 study · 22 participants | Ungraded |
Metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.04 [-0.43, 0.50] | 4 studies · 108 participants | Ungraded |
Clindamycin + SRP vs Metronidazole + SRP Adverse events · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included study has not reported adverse events | NR | No studies |
Metronidazole + SRP vs Amoxicillin + metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 4.46 [-23.48, 32.40] | 3 studies · 84 participants | Ungraded |
Doxycycline + SRP vs Metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.07 [-0.29, 0.15] | 1 study · 22 participants | Ungraded |
Azithromycin + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Doxycycline + SRP vs Amoxicillin + metronidazole + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.20 [0.06, 0.33] | 2 studies · 50 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Clinical attachment level (CAL) · Adults with chronic periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.10 [-0.51, 0.71] | 1 study · 21 participants | Very low |
Metronidazole + SRP vs SRP Antimicrobial resistance · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Levofloxacin + SRP vs SRP Probing pocket depth · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.09 [-1.33, -0.85] | 2 studies · 131 participants | Ungraded |
Moxifloxacin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -3.40 [-3.72, -3.08] | 1 study · 40 participants | Ungraded |
Doxycycline + SRP vs SRP Percentage of closed pockets · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Doxycycline + SRP vs Metronidazole + SRP Percentage of closed pockets · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Metronidazole + SRP vs SRP Percentage of closed pockets · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -2.56 [-12.33, 7.22] | 2 studies · 51 participants | Ungraded |
Azithromycin + SRP vs SRP Adverse events · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | 1 study reported diarrhoea, headache or dizziness, metallic taste, and general unwellness by 4 participants from the intervention group and 3 from the control group. In 1 study none of the participants reported any… | 2 studies · 110 participants | Very low |
Metronidazole + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -4.62 [-18.83, 9.58] | 2 studies · 45 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Probing pocket depth · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.20 [-0.02, 0.42] | 1 study · 21 participants | Ungraded |
Amoxicillin + metronidazole + SRP vs SRP Adverse events · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Most common adverse events were mild gastrointestinal disturbances, nausea and vomiting, metallic taste, and diarrhoea in the intervention group. Control group reported adverse events like hypothermia, mild… | 2 studies · 389 participants | Very low |
Metronidazole + SRP vs SRP Probing pocket depth · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.10 [-0.37, 0.16] | 4 studies · 108 participants | Ungraded |
Metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.12 [-2.24, 0.00] | 3 studies · 71 participants | Very low |
Clindamycin + SRP vs Doxycycline + SRP Adverse events · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included study has not reported adverse events | NR | No studies |
Amoxicillin + clavulanate + SRP vs SRP Clinical attachment level (CAL) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.10 [-0.43, 0.63] | 1 study · 21 participants | Ungraded |
Levofloxacin + SRP vs SRP Clinical attachment level (CAL) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.02 [-1.39, -0.65] | 2 studies · 131 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.10 [-0.19, -0.01] | 1 study · 21 participants | Ungraded |
Clindamycin + SRP vs Metronidazole + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.20 [-0.55, 0.95] | 1 study · 26 participants | Very low |
Metronidazole + SRP vs SRP Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Clindamycin + SRP vs Metronidazole + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.10 [-0.60, 0.80] | 1 study · 26 participants | Ungraded |
Azithromycin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -3.18 [-7.01, 0.65] | 6 studies · 216 participants | Ungraded |
Levofloxacin + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with chronic periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.93 [-2.88, 1.02] | 2 studies · 131 participants | Ungraded |
Clindamycin + SRP vs Doxycycline + SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Levofloxacin + SRP vs SRP Clinical attachment level (CAL) · Adults with chronic periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -1.25 [-1.51, -0.99] | 2 studies · 131 participants | Ungraded |
Metronidazole + SRP vs Amoxicillin + metronidazole + SRP Percentage of bleeding on probing (BOP) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 20.85 [3.31, 38.39] | 1 study · 22 participants | Ungraded |
Clindamycin + SRP vs Doxycycline + SRP Probing pocket depth · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.40 [-1.14, 0.34] | 1 study · 23 participants | Ungraded |
Doxycycline + SRP vs SRP Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.09 [-0.29, 0.11] | 1 study · 21 participants | Ungraded |
Clindamycin + SRP vs Metronidazole + SRP Probing pocket depth · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.20 [-0.38, 0.78] | 1 study · 26 participants | Very low |
Clindamycin + SRP vs Doxycycline + SRP Clinical attachment level (CAL) · Adults with aggressive periodontitis · Short-term (≤ 3 months) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD 0.50 [-0.26, 1.26] | 1 study · 23 participants | Ungraded |
Amoxicillin + clavulanate + SRP vs Tetracycline + SRP Probing pocket depth · Adults with aggressive periodontitis · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.40 [-1.11, 0.31] | 1 study · 8 participants | Ungraded |
Clindamycin + SRP vs Doxycycline + SRP Percentage of closed pockets · Adults with aggressive periodontitis · Long-term (≥ 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | Included studies have not reported this outcome | NR | No studies |
Metronidazole + SRP vs SRP Clinical attachment level (CAL) · Adults with periodontitis (chronic and aggressive) · Intermediate-term (> 3 months to < 1 year) Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane | MD -0.49 [-1.29, 0.31] | 4 studies · 94 participants | Ungraded |