Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether abdominal dermal fat graft changes maximal mouth opening (interincisal distance) compared with nasolabial flap (very low certainty).
2 findings from 1 review
MD -14.87 [-19.93, -9.81]
1 study · 30 participants
Very low
MD -3.60 [-5.17, -2.03]
1 study · 30 participants
Very low
Alignment rate · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
It is very uncertain whether thermoelastic copper NiTi (CuNiTi) arch wire changes alignment rate compared with conventional NiTi arch wire (very low certainty).
1 finding from 1 review
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after submucosal instrumentation (SI) vs Submucosal instrumentation (SI) alone, or SI plus placebo/sham aPDT
Outcome not reported · Adults (> 18 years) with peri-implant mucositis, receiving supportive treatment
The review found no eligible studies for this question.
1 finding from 1 review
Mother microbiological presence (mutans streptococci colonisation level, CFU/mL) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
Consumption of xylitol chewing gum by women (mothers) led to higher mother microbiological presence (mutans streptococci colonisation… compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to…; GRADE not reported.
1 finding from 1 review
ANB · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask probably leads to higher ANB compared with untreated control (no treatment) (moderate certainty).
3 findings from 1 review
MD 1.40 [0.43, 2.37]
1 study · 63 participants
Moderate
MD 0.70 [-0.74, 2.14]
1 study · 65 participants
Low
MD 3.60 [2.68, 4.52]
5 studies · 197 participants
GRADE not reported
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether vasodilators (isoxsuprine, xanthinol nicotinate) changes burning sensation (VAS 0-100) compared with placebo or no active treatment (very low certainty).
2 findings from 1 review
MD -51.02 [-72.85, -29.20]
2 studies · 85 participants
Very low
MD -38.79 [-52.06, -25.53]
2 studies · 85 participants
Very low
Adverse effects · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
1 finding from 1 review
Galeotti 2021: occasional skin irritation on the chin and three appliance breakages (one facemask, two Pushing Splints).
1 study · 42 participants
GRADE not reported
Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
It is very uncertain whether topical curcumin gel changes burning sensation (VAS 0-100) compared with topical aloe vera gel (very low certainty).
1 finding from 1 review
defs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age
It is very uncertain whether consumption of xylitol chewing gum by women (mothers) changes defs index score (categories) compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to… (very low certainty).
2 findings from 1 review
Thorild 2003 defs score categories (very low-certainty): 1-3 defs RR 0.48 (95% CI 0.15 to 1.54); 3-4 defs RR 0.85 (95% CI 0.18 to 3.98); >=5 defs RR 0.28 (95% CI 0.01 to 6.78); 96 participants.
1 study · 96 participants
Very low
MD -0.28 [-0.83, 0.27]
1 study · 96 participants
Very low
Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask (RME) or modified facemask showed no clear difference in wits appraisal compared with surgically-anchored appliance (miniscrews or miniplates); GRADE not reported.
1 finding from 1 review
Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask with rapid maxillary expansion (RME) showed no clear difference in overjet compared with pushing Splints; GRADE not reported.
1 finding from 1 review
Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
Change in bleeding on probing (BOP) · Adults (> 18 years) with recurrent periodontitis, receiving supportive (maintenance) periodontal care
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… showed no clear difference in change in bleeding on probing (BOP) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
2 findings from 1 review
Intolerance to spicy food (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
Antioxidants (lycopene, curcumin, Oxitard) led to lower intolerance to spicy food (participant-reported proxy) compared with placebo or no active treatment; GRADE not reported.
1 finding from 1 review
Muscle pain when chewing · People with temporomandibular disorders (TMD)
It is very uncertain whether occlusal splint changes muscle pain when chewing compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).
1 finding from 1 review
Pain at 72 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)
It is very uncertain whether postoperative systemic antibiotics… changes pain at 72 hours compared with matched placebo, partial or total chemo-mechanical debridement and… (very low certainty).
1 finding from 1 review
Self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)
Facemask led to lower self-esteem (Oral Aesthetic Subjective Impact Score, OASIS) compared with untreated control (no treatment); GRADE not reported.
3 findings from 1 review
MD -4.00 [-7.40, -0.60]
1 study · 69 participants
GRADE not reported
MD -2.20 [-7.31, 2.91]
1 study · 65 participants
GRADE not reported
MD -3.40 [-7.99, 1.19]
1 study · 63 participants
GRADE not reported
Change in bleeding on probing (BOP) · Adults (> 18 years) with a clinical diagnosis of periodontitis, receiving active (non-surgical anti-infective) treatment
It is very uncertain whether adjunctive antimicrobial photodynamic therapy (aPDT) applied after… changes change in bleeding on probing (BOP) compared with subgingival instrumentation (SI) alone (hand or power-driven, or… (very low certainty).
2 findings from 1 review
Patient discomfort · People with temporomandibular disorders (TMD)
The review found no eligible studies for this question.
1 finding from 1 review
Pain day 1 · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Superelastic NiTi arch wire showed no clear difference in pain day 1 compared with conventional (stabilised) NiTi arch wire (low certainty).
1 finding from 1 review