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What do systematic reviews say?

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Evidence found and GRADE certainty

181 questions · 190 findings · 14 reviews · Headline outcomes only

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No studies found 92 · 48.4%GRADE not reported 1 · 0.5%Very low 64 · 33.7%Low 25 · 13.2%Moderate 7 · 3.7%High 1 · 0.5%

Silver‐based antiseptics vs topical antibiotics

Time to complete healing · people with burns

Silver‐based antiseptics showed no clear difference in wound healing: time to complete healing (time‐to‐event data) compared with topical antibiotics (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    HR 1.25 [0.94, 1.67]
    3 studies · 259 participants
    Low

Honey vs topical antibiotics

Peristent infection: honey versus SSD · people with burns

It is very uncertain whether honey changes peristent infection: honey versus SSD compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.1 [0.05, 0.19]
    2 studies · 170 participants
    Very low

Honey vs topical antibiotics

Adverse events: honey versus SSD · people with burns

It is very uncertain whether honey changes adverse events: honey versus SSD compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.2 [0.01, 3.97]
    3 studies · 250 participants
    Very low

Aloe vera vs topical antibiotics

Wound healing · people with burns

Aloe vera showed no clear difference in wound healing (number of healing events): Aloe Vera versus SSD compared with topical antibiotics (low certainty).

2 findings from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.41 [0.7, 2.85]
    1 study · 38 participants
    Low
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 210 participants
    Very low

Aloe vera vs topical antibiotics

Infection: Aloe Vera versus SSD · people with burns

It is very uncertain whether aloe vera changes infection: Aloe Vera versus SSD compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.93 [0.26, 3.34]
    3 studies · 221 participants
    Very low

Iodine vs topical antibiotics

Wound healing · people with burns

It is very uncertain whether iodine changes wound healing (mean time to healing) compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 148 participants
    Very low

Iodine vs topical antibiotics

Infection · people with burns

The review found no eligible studies for this question.

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Iodine vs topical antibiotics

Adverse events · people with burns

It is very uncertain whether iodine changes adverse events compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.86 [0.35, 2.1]
    1 study · 40 participants
    Very low

Silver‐based antiseptics vs topical antibiotics

Wound healing · people with burns

Silver‐based antiseptics showed no clear difference in wound healing (mean time to healing) compared with topical antibiotics (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    10 studies · 1085 participants
    Low

Silver‐based antiseptics vs topical antibiotics

Number of wounds healed · people with burns

Silver‐based antiseptics showed no clear difference in wound healing (number of healing events) compared with topical antibiotics (low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 1.17 [1, 1.37]
    5 studies · 408 participants
    Low

Honey vs topical antibiotics

Time to complete healing · people with burns

Honey probably leads to higher wound healing: time to complete healing (time‐to‐event data): honey… compared with topical antibiotics (moderate certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    HR 2.45 [1.71, 3.52]
    5 studies · 580 participants
    Moderate

Honey vs topical antibiotics

Wound healing · people with burns

It is very uncertain whether honey changes wound healing (mean time to healing): honey versus SSD compared with topical antibiotics (very low certainty).

2 findings from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    no estimate extracted
    6 studies · 712 participants
    Very low
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 2.18 [1.15, 4.13]
    4 studies · 318 participants
    Low

Honey vs topical antibiotics

Incident infection: honey versus SSD or mafenide acetate · people with burns

It is very uncertain whether honey changes incident infection: honey versus SSD or mafenide acetate compared with topical antibiotics (very low certainty).

1 finding from 1 review
  • Antiseptics for burns 2017 · Cochrane Headline outcomes only
    RR 0.16 [0.08, 0.34]
    4 studies · 480 participants
    Very low