Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

189 questions · 190 findings · 12 reviews · Eyes and Vision

No studies found 57 · 30%GRADE not reported 4 · 2.1%Very low 53 · 27.9%Low 33 · 17.4%Moderate 28 · 14.7%High 15 · 7.9%

Summary of findings: intravitreal bevacizumab plus intravitreal steroid vs macular laser

Development of cataract at · adults with centre‐involving diabetic macular oedema

It is very uncertain whether summary of findings: intravitreal bevacizumab plus intravitreal… changes development of cataract at compared with macular laser (very low certainty).

1 finding from 1 review

Summary of findings: intravitreal bevacizumab plus intravitreal steroid vs macular laser

Raised Intraocular Pressure at · adults with centre‐involving diabetic macular oedema

It is very uncertain whether summary of findings: intravitreal bevacizumab plus intravitreal… changes raised Intraocular Pressure at compared with macular laser (very low certainty).

1 finding from 1 review

Summary of findings: intravitreal bevacizumab plus intravitreal steroid vs intravitreal steroid

Raised Intraocular Pressure at · adults with centre‐involving diabetic macular oedema

It is very uncertain whether summary of findings: intravitreal bevacizumab plus intravitreal… changes raised intraocular pressure at 1 year at compared with intravitreal steroid (very low certainty).

1 finding from 1 review

Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham

Safety: Development of macular neovascularisation or exudative AMD at 1 year · adults with GA due to AMD

Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in safety: Development of macular neovascularisation or exudative AMD… compared with sham (low certainty).

1 finding from 1 review

Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham

Safety: Development of endophthalmitis at 1 year · adults with GA due to AMD

Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in safety: Development of endophthalmitis at 1 year compared with sham (moderate certainty).

1 finding from 1 review

Summary of findings 1: Efficacy and safety of IVT lampalizumab 4‐weekly (monthly) vs sham

Loss of ≥ 15 letters BCVA at 1 year · adults with GA due to AMD

Summary of findings 1: Efficacy and safety of IVT lampalizumab… showed no clear difference in loss of ≥ 15 letters BCVA at 1 year compared with sham (moderate certainty).

1 finding from 1 review