Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 151 findings · 21 reviews

No studies found 23 · 15.2%GRADE not reported 19 · 12.6%Very low 32 · 21.2%Low 35 · 23.2%Moderate 28 · 18.5%High 14 · 9.3%

Statins vs placebo

Total VTE · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower all cases of VTE compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Any MI · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower any MI compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Stroke · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower any stroke compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Death · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin probably leads to lower death compared with placebo (moderate certainty).

1 finding from 1 review

Statins vs placebo

Any serious adverse event · 17,802 patients with low to normal levels of low density lipoprotein (LDL) cholesterol (< 130 mg/dL)

Statin showed no clear difference in any serious adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Major cardiovascular events · adults with chronic kidney disease

The intervention showed no clear difference in major cardiovascular events (high certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality · adults with chronic kidney disease

The intervention showed no clear difference in all‐cause mortality (moderate certainty).

1 finding from 1 review

Intervention not reported

Cardiovascular mortality · adults with chronic kidney disease

The intervention showed no clear difference in cardiovascular mortality (moderate certainty).

1 finding from 1 review