Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

177 questions · 178 findings · 33 reviews · Headline outcomes only

No studies found 62 · 34.8%GRADE not reported 10 · 5.6%Very low 47 · 26.4%Low 40 · 22.5%Moderate 18 · 10.1%High 1 · 0.6%

Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique

Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts

It is very uncertain whether pharmacomechanical thrombolysis (Cragg® catheter) changes minor adverse events compared with pulse spray technique (very low certainty).

1 finding from 1 review

Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique

Major adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts

It is very uncertain whether pharmacomechanical thrombolysis (Cragg® catheter) changes major adverse events compared with pulse spray technique (very low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Complete remission · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in treatment response at 52 weeks: complete remission (primary outcome… compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Partial remission ( · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in treatment response at 52 weeks: partial remission (primary outcome 3) compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Sustainable remission between 52 and 78 weeks: complete or partial remission (primary outcome 1, 2, 3) · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in sustainable remission between 52 and 78 weeks: complete or partial… compared with mycophenolate mofetil with pulse dexamethasone (moderate certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

CKD or death: 50% decline in GFR by 78 weeks · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in CKD or death: 50% decline in GFR by 78 weeks compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse effects (weeks 0 to 26): serious infection requiring hospitalisation · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): serious infection requiring… compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review