Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

707 questions · 750 findings · 36 reviews

No studies found 56 · 7.5%GRADE not reported 200 · 26.7%Very low 142 · 18.9%Low 186 · 24.8%Moderate 132 · 17.6%High 34 · 4.5%

Transference‐Focused Psychotherapy (TFP) vs community treatment by experts (CTBE)

Suicidality ‐ CBT vs. TAUno. of participants with suicidal act (last 12 months) · patients with borderline personality disorder

Transference‐Focused Psychotherapy (TFP) showed no clear difference in suicidalityno. of participants with suicidal act (last 12 months) compared with community treatment by experts (CTBE) (moderate certainty).

1 finding from 1 review

Transference‐Focused Psychotherapy (TFP) vs community treatment by experts (CTBE)

Parasuicidality ‐ CBT vs. TAUno. of participants with self‐harming behaviour (last 12 months) · patients with borderline personality disorder

Transference‐Focused Psychotherapy (TFP) showed no clear difference in parasuicidalityno. of participants with self‐harming behaviour (last… compared with community treatment by experts (CTBE) (moderate certainty).

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (any severity) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (any severity) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (moderate to severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (moderate to severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Chlorhexidine vs Cryotherapy (ice chips) 60 minutes

Oral mucositis (severe) · Patients with cancer receiving radiotherapy, chemotherapy or targeted therapies

Chlorhexidine showed no clear difference in oral mucositis (severe) compared with cryotherapy (ice chips); GRADE not reported.

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Depressive symptoms · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care showed no clear difference in self‐reported depressive symptoms short term (up to 6 months) ‐ BDI… compared with usual care alone (moderate certainty).

8 findings from 1 review
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Psychotherapy as an adjunct to usual care vs usual care

Dropout · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care showed no clear difference in dropout medium term (7 to 12 months)* compared with usual care alone (moderate certainty).

2 findings from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Response (50% reduction in BDI) medium term (7 to 12 months)* · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in BDI) medium term (7 to 12 months)* compared with usual care alone (low certainty).

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Response (50% reduction in BDI) long term (longer than 12 months)* · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in BDI) long term (longer than 12 months)* compared with usual care alone (low certainty).

1 finding from 1 review

Psychotherapy as an adjunct to usual care vs usual care

Remission · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care probably leads to higher remission (< 7 on HAMD or < 10 on BDI) medium term (7 to 12 months)* compared with usual care alone (moderate certainty).

2 findings from 1 review

Psychotherapy as an adjunct to usual care vs usual care

> 50% reduction in depressive symptoms · treatment‐resistant depression in adults

Psychotherapy as an adjunct to usual care may leads to higher response (50% reduction in depressive symptoms from baseline) short… compared with usual care alone (low certainty).

1 finding from 1 review

Dynamic‐Deconstructive Psychotherapy (DDP) vs treatment

Parasuicidalityno. of participants with parasuicide (last 3 months) · patients with borderline personality disorder

Dynamic‐Deconstructive Psychotherapy (DDP) showed no clear difference in parasuicidalityno. of participants with parasuicide (last 3 months) compared with treatment (low certainty).

1 finding from 1 review