Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,536 questions · 2,637 findings · 315 reviews

No studies found 608 · 23.1%GRADE not reported 488 · 18.5%Very low 688 · 26.1%Low 540 · 20.5%Moderate 249 · 9.4%High 64 · 2.4%

Multi‐component intervention vs usual care or attention control

Falls · Older people living in the community

Multiple component interventions probably leads to lower rate of falls (falls per person years) compared with usual care or attention control (moderate certainty).

1 finding from 1 review

Multi‐component intervention vs usual care or attention control

Number of people sustaining recurrent falls (defined as two or more falls in a specified time period) · Older people living in the community

Multiple component interventions showed no clear difference in number of people sustaining recurrent falls (defined as two or more… compared with usual care or attention control (low certainty).

1 finding from 1 review

Multi‐component intervention vs usual care or attention control

Number of people who experience a fall that required hospital admission · Older people living in the community

It is very uncertain whether multiple component interventions changes number of people who experience a fall that required hospital… compared with usual care or attention control (very low certainty).

1 finding from 1 review

Multi‐component intervention vs usual care or attention control

Number of people who experience a fall that required medical attention · Older people living in the community

Multiple component interventions showed no clear difference in number of people who experience a fall that required medical attention compared with usual care or attention control (low certainty).

1 finding from 1 review

Multi‐component intervention vs exercise

Number of people who experience a fall that required hospital admission · Older people living in the community

It is very uncertain whether multiple component interventions changes number of people who experience a fall that require hospital admission compared with exercise (very low certainty).

1 finding from 1 review

Primary care physician alerting system and a patient‐directed intervention (education and reminder to see their primary care physician) vs usual care

Bone mineral density · General practitioners/family doctors involved in the management of patients with osteoporosis

Primary care physician alerting system and a patient‐directed… leads to higher bone Mineral Density 1 compared with standard care (high certainty).

1 finding from 1 review

Platelet-rich fibrin after bone surgery vs Bone surgery alone

Healing of MRONJ (mucosal integrity, absence of infection, and no re-intervention) · People with established (manifest) MRONJ

It is very uncertain whether platelet-rich fibrin after bone surgery changes healing of MRONJ (mucosal integrity, absence of infection, and no… compared with bone surgery alone (very low certainty).

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Perimplant bone loss · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in perimplant bone loss compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Inlay bone substitute (Bio-Oss block)

Vertical bone gain · Patients with atrophic posterior mandibles (5 to 7 mm above the mandibular canal) needing implants

Inlay autogenous bone graft (iliac crest) showed no clear difference in vertical bone gain compared with inlay bone substitute (Bio-Oss block); GRADE not reported.

1 finding from 1 review

Inlay autogenous bone graft (iliac crest) vs Autogenous onlay bone graft (iliac crest)

Vertical bone gain · Patients with deficient posterior mandibles (4.5 to 10 mm above the mandibular canal) needing implants

Autogenous inlay bone graft (iliac crest) showed no clear difference in vertical bone gain compared with autogenous onlay bone graft (iliac crest); GRADE not reported.

1 finding from 1 review

Vertical GBR with autogenous bone (retromolar) vs Vertical GBR with bone substitute (Regenaform)

Vertical bone gain · Patients with vertically deficient posterior/anterior mandibular ridges needing implants

Vertical GBR with autogenous bone (retromolar) led to higher vertical bone gain compared with vertical GBR with bone substitute (Regenaform); GRADE not reported.

1 finding from 1 review