Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,310 questions · 1,358 findings · 214 reviews

No studies found 230 · 16.9%GRADE not reported 169 · 12.4%Very low 269 · 19.8%Low 277 · 20.4%Moderate 291 · 21.4%High 122 · 9%

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Perineal pain within 4 ‐ 6 hours of giving birth ‐ Moderate + severe pain · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes perineal pain within 4 ‐ 6 hours of giving birth ‐ Moderate + severe… compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Perineal pain within 24 hours of giving birth ‐ Moderate + severe pain · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes perineal pain within 24 hours of giving birth ‐ Moderate + severe pain compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs cooling treatment (cold gel pad)

Perineal pain 24 ‐ 48 hours after giving birth ‐ Moderate + severe pain · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack) changes perineal pain 24 ‐ 48 hours after giving birth ‐ Moderate + severe… compared with cooling treatment (cold gel pad) (very low certainty).

1 finding from 1 review

Cooling treatment (ice pack) vs no treatment

Perineal pain 24 ‐ 48 hours after giving birth ‐ Moderate + severe pain · Women with perineal trauma (tear or episiotomy, or both) sustained during childbirth

It is very uncertain whether cooling treatment (ice pack or cold gel pad) changes perineal pain between 24 ‐ 48 after giving birth ‐ Moderate + severe… compared with no treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Cramp intensity (moderate or worse at 4 weeks) · pregnant women with leg cramps

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Cramp intensity (moderate or worse at 4 weeks) · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in cramp intensity (moderate or worse at 4 weeks) (moderate certainty).

1 finding from 1 review

Regimens containing macrolides (azithromycin) vs regimens containing tetracycline (doxycycline)

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

It is very uncertain whether regimens containing macrolides (azithromycin) changes clinical cure according to criteria established by study authors… compared with regimens containing tetracycline (doxycycline) (very low certainty).

2 findings from 1 review

Regimens containing nitroimidazole vs no nitroimidazole

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

Regimens containing nitroimidazole showed no clear difference in clinical cure according to criteria established by study authors… compared with no nitroimidazole (moderate certainty).

2 findings from 1 review

Clindamycin plus aminoglycoside vs regimens containing quinolone

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

It is very uncertain whether regimens containing clindamycin plus aminoglycoside changes clinical cure according to criteria established by authors… compared with regimens containing quinolone (very low certainty).

1 finding from 1 review

Clindamycin plus aminoglycoside vs regimens containing cephalosporin

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

Regimens containing clindamycin plus aminoglycoside showed no clear difference in clinical cure according to criteria established by authors… compared with regimens containing cephalosporin (low certainty).

1 finding from 1 review

Regimens containing quinolone vs regimens containing cephalosporin

Clinical cure according to criteria established by study authors Mild‐moderate PID · women with PID

Regimens containing quinolone showed no clear difference in clinical cure according to criteria established by study authors… compared with regimens containing cephalosporins (low certainty).

1 finding from 1 review

Salicylic acid vs tretinoin

Participants' global self‐assessment of acne improvement Moderate to excellent improvement (long term: treatment duration > 8 weeks) · participants with acne

Salicylic acid showed no clear difference in participants' global self‐assessment of acne improvement Moderate to… compared with tretinoin (low certainty).

1 finding from 1 review