What do systematic reviews say?

Naftopidil vs tamsulosin

Naftopidil showed no clear difference in cardiovascular adverse events compared with tamsulosin (alpha‐blocker) (low certainty).

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 0.97 [0.52, 1.8]
  9 studies · 824 participants
  Low

Naftopidil vs tamsulosin

Naftopidil showed no clear difference in sexual adverse events compared with tamsulosin (alpha‐blocker) (low certainty).

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 0.54 [0.24, 1.22]
  5 studies · 397 participants
  Low

Naftopidil vs silodosin (alpha‐blocker)

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 652 participants
  Low

Naftopidil vs silodosin (alpha‐blocker)

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 652 participants
  Low

Naftopidil vs silodosin (alpha‐blocker)

Naftopidil showed no clear difference in treatment withdrawals for any reason compared with silodosin (alpha‐blocker) (low certainty).

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 0.8 [0.52, 1.23]
  4 studies · 659 participants
  Low

Naftopidil vs silodosin (alpha‐blocker)

Naftopidil showed no clear difference in cardiovascular adverse events compared with silodosin (alpha‐blocker) (low certainty).

• Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.39, 2.44]
  5 studies · 808 participants
  Low

PDEI vs placebo

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 4293 participants
  Low

PDEI plus alpha‐blocker vs PDEI alone

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Low

PDEI plus alpha‐blocker vs PDEI alone

The review found no eligible studies for this question.

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

PDEI plus alpha‐blocker vs PDEI alone

The review found no eligible studies for this question.

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

PDEI + 5‐ARI vs 5‐ARI alone

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 695 participants
  Moderate
• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 695 participants
  Moderate

PDEI + 5‐ARI vs 5‐ARI alone

The review found no eligible studies for this question.

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

PDEI + 5‐ARI vs 5‐ARI alone

The review found no eligible studies for this question.

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 1.07 [0.84, 1.36]
  1 study · 695 participants
  Low

PDEI vs placebo

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 3646 participants
  Low

PDEI vs placebo

PDEI may leads to higher adverse events compared with placebo (low certainty).

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 1.42 [1.21, 1.67]
  11 studies · 4386 participants
  Low

PDEI vs alpha‐blocker

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 933 participants
  Moderate

PDEI vs alpha‐blocker

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 550 participants
  Low

PDEI vs alpha‐blocker

PDEI showed no clear difference in adverse events compared with alpha‐blockers (low certainty).

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 1.35 [0.8, 2.3]
  4 studies · 786 participants
  Low

PDEI plus alpha‐blocker vs alpha‐blocker

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 193 participants
  Low

PDEI plus alpha‐blocker vs alpha‐blocker

The review found no eligible studies for this question.

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found