Findings

What do systematic reviews say?

143 questions · 144 findings · 9 reviews

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No studies found 41 · 28.5%GRADE not reported 8 · 5.6%Very low 26 · 18.1%Low 31 · 21.5%Moderate 25 · 17.4%High 13 · 9%

Valproate vs lithium

Adverse events: somnolence/sedation · Children and adolescents with acute mania

It is very uncertain whether valproate changes individual adverse events ‐ Sedation At 8 weeks (secondary… compared with lithium (very low certainty).

1 finding from 1 review

Valproate for acute mania 2019 · Cochrane Headline outcomes only
OR 1.59 [0.84, 3]
1 study · 190 participants
Very low

Valproate vs lithium

Change in symptom severity of mania rating scale at 8 weeks (secondary efficacy outcome) · Children and adolescents with acute mania

1 finding from 1 review

Valproate for acute mania 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 190 participants
Very low

Valproate vs lithium

Dropout · Children and adolescents with acute mania

It is very uncertain whether valproate changes dropout rate ‐ All‐cause At 8 weeks (secondary acceptability outcome) compared with lithium (very low certainty).

1 finding from 1 review

Valproate for acute mania 2019 · Cochrane Headline outcomes only
OR 0.74 [0.39, 1.37]
1 study · 197 participants
Very low