Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

579 questions · 601 findings · 56 reviews

No studies found 143 · 23.8%GRADE not reported 69 · 11.5%Very low 101 · 16.8%Low 142 · 23.6%Moderate 116 · 19.3%High 30 · 5%

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Anaemia · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… may leads to lower anaemia (haemoglobin concentration below a cut‐off defined by the… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Iron deficiency (as defined by trialists) · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in iron deficiency (as defined by trialists by using indicators of iron… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Iron deficiency anaemia · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in iron deficiency anaemia (as defined by the presence of anaemia plus… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

All‐cause morbidity · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in all‐cause morbidity (the most frequent event associated with the… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Side effects or other adverse events · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in any adverse side effects compared with no supplementation or placebo (moderate certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Low birthweight · Women receiving supplements in pregnancy

Any intermittent iron regimen (with or without other vitamins and… showed no clear difference in low birthweight (less than 2500 g) compared with daily regimen (with same vitamins and minerals)‐infant outcomes (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Participants with at least some Side Effects · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes side effects (any reported throughout intervention period) compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review