Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

374 questions · 393 findings · 47 reviews · Headline outcomes only

No studies found 73 · 18.6%GRADE not reported 16 · 4.1%Very low 164 · 41.7%Low 85 · 21.6%Moderate 36 · 9.2%High 19 · 4.8%

Casirivimab/imdevimab vs placebo

Development of clinical COVID‐19 symptoms within 30 days · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab leads to lower development of clinical COVID‐19 symptoms within 30 days compared with placebo (high certainty).

1 finding from 1 review

Casirivimab/imdevimab vs placebo

Serious adverse events until data cut‐offb · SARS‐CoV‐2 uninfected people without defined exposure, or with potential exposure to SARS‐CoV‐2

Casirivimab/imdevimab showed no clear difference in serious adverse events until data cut‐offb compared with placebo (low certainty).

1 finding from 1 review