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Evidence found and GRADE certainty

643 questions · 693 findings · 156 reviews

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No studies found 177 · 25.5%GRADE not reported 100 · 14.4%Very low 144 · 20.8%Low 139 · 20.1%Moderate 106 · 15.3%High 27 · 3.9%

Hysterectomy (radical) with neoadjuvant chemotherapy vs chemoradiotherapy alone

SAEs and toxicity · women with locally advanced cervical cancer

It is very uncertain whether hysterectomy (radical) with neoadjuvant chemotherapy changes SAEs and toxicity compared with chemoradiotherapy alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

It is very uncertain whether hysterectomy (simple or radical) with chemoradiotherapy changes overall survival Median compared with chemoradiotherapy alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with chemoradiotherapy vs chemoradiotherapy alone

Progression or event‐free survival Median · women with locally advanced cervical cancer

It is very uncertain whether hysterectomy (simple or radical) with chemoradiotherapy changes progression or event‐free survival Median compared with chemoradiotherapy alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Death (all causes) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with neoadjuvant chemotherapy probably leads to lower overall survival Median compared with radiotherapy alone (moderate certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Disease or progression‐free survival Median · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with neoadjuvant chemotherapy showed no clear difference in disease‐ or progression‐free survival Median compared with radiotherapy alone (moderate certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with neoadjuvant chemotherapy vs Radiotherapy alone

Severe adverse events and toxicity · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with neoadjuvant chemotherapy showed no clear difference in severe adverse events and toxicity compared with radiotherapy alone (low certainty).

1 finding from 1 review

PFMT added to electrical stimulation vs pelvic floor muscle training (PFMT)

Participants with improvement in urgency urinary incontinence · Adults with overactive bladder (OAB)

Electrical stimulation plus pelvic floor muscle training (PFMT) may leads to higher participants with improvement in urgency urinary incontinence compared with PFMT alone (low certainty).

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

COVID-19 viral content of aerosol (when present) · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Other adverse events (allergy, irritation/burning of nasal, oral or oropharyngeal mucosa, long-term staining of mucous membranes or teeth, accidental ingestion) · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Anosmia (or disturbance in sense of smell) · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Change in viral load · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

RECOVERY trial outcomes (mortality; hospitalisation status; use of ventilation; use of renal dialysis or haemofiltration) · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Changes in microbiome in oral cavity, nasal cavity, oro- or nasopharynx · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated nets (ITNs) vs ITNs alone

Malaria incidence · people at risk of malaria

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated… showed no clear difference in malaria incidence compared with ITNs alone (moderate certainty).

1 finding from 1 review

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated nets (ITNs) vs ITNs alone

Malaria parasite prevalence · people at risk of malaria

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated… showed no clear difference in malaria parasite prevalence compared with ITNs alone (moderate certainty).

1 finding from 1 review