Findings

What do systematic reviews say?

149 questions · 159 findings · 18 reviews

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No studies found 21 · 13.2%GRADE not reported 8 · 5%Very low 33 · 20.8%Low 62 · 39%Moderate 29 · 18.2%High 6 · 3.8%

IV cyclophosphamide vs IV dexamethasone and oral cyclophosphamide

Adverse effects ‐ Bacterial infection clinical assessment · idiopathic steroid‐resistant nephrotic syndrome in children

IV cyclophosphamide showed no clear difference in adverse events: bacterial infections compared with oral cyclophosphamide plus IV dexamethasone (low certainty).

1 finding from 1 review

Interventions for idiopathic steroid‐resistant nephrotic syndrome in children 2019 · Cochrane Headline outcomes only
RR 0.66 [0.27, 1.63]
1 study · 49 participants
Low

Adults: prednisolone vs dexamethasone

Exacerbations · Adults with acute asthma

It is very uncertain whether adults: prednisolone changes new exacerbation during compared with dexamethasone (very low certainty).

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.32 [0.39, 4.47]
1 study · 200 participants
Very low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.85 [0.43, 7.96]
1 study · 200 participants
Very low

Children: prednisolone vs dexamethasone

Admission to hospital at initial presentation · children with acute asthma

Children: prednisolone showed no clear difference in admission at initial presentation compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 1.08 [0.74, 1.58]
3 studies · 1007 participants
Low

Children: prednisolone vs dexamethasone

Re‐admission during · children with acute asthma

Children: prednisolone showed no clear difference in re‐admission during compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.44 [0.15, 1.33]
3 studies · 985 participants
Low

Children: prednisolone vs dexamethasone

Asthma symptoms · children with acute asthma

2 findings from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 328 participants
Very low
Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 533 participants
GRADE not reported

Children: prednisolone vs dexamethasone

Serious adverse events · children with acute asthma

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 255 participants
GRADE not reported

Children: prednisolone vs dexamethasone

Exacerbations · children with acute asthma

Children: prednisolone showed no clear difference in new exacerbation during compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.85 [0.54, 1.34]
4 studies · 981 participants
Low

Adults: prednisolone vs dexamethasone

Re‐admission during · Adults with acute asthma

It is very uncertain whether adults: prednisolone changes re‐admission during compared with dexamethasone (very low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.35 [0.04, 3.47]
1 study · 200 participants
Very low

Adults: prednisolone vs dexamethasone

Asthma symptoms Returned to normal activities within 3 days · Adults with acute asthma

Adults: prednisolone showed no clear difference in asthma symptoms Returned to normal activities within 3 days compared with dexamethasone (low certainty).

1 finding from 1 review

Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
OR 0.44 [0.19, 1.01]
1 study · 191 participants
Low