What do systematic reviews say?

Interdental brushing plus toothbrushing vs Toothbrushing alone

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
  One study measured probing pocket depth but no data were reported (Graziani 2017).
  1 study
  GRADE not reported

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Interdental brushing plus toothbrushing showed no clear difference in periodontitis (probing pocket depth) compared with flossing plus toothbrushing (low certainty).

• Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes

  4 to 6 weeks
  MD -0.06 [-0.27, 0.16]
  3 studies · 107 participants
  Low

Interdental brushing plus toothbrushing vs Toothbrushing alone

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed bad breath as an outcome. (See comment)
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed bad breath as an outcome. (See comment)
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Toothbrushing alone

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed quality of life as an outcome. (See comment)
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed quality of life as an outcome. (See comment)
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Toothbrushing alone

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed periodontitis as an outcome. (See comment)
  0 studies
  No studies found

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

The review found no eligible studies for this question.

• Interdental brushing for the prevention and control of periodontal diseases and dental caries in adults 2013 · Cochrane All outcomes
  Not estimable. No included study assessed clinical attachment loss, a measure of progression of periodontitis. (See comment)
  0 studies
  No studies found

Slow-release fluoride device (fluoride glass beads) vs placebo or usual care

The review found no eligible studies for this question.

• Slow‐release fluoride devices for the control of dental decay 2018 · Cochrane All outcomes
  No evidence found
  0 studies
  No studies found

Glass ionomer sealant (with fluoride gel plus dentifrice) vs Fluoride gel plus fluoride toothpaste/dentifrice (non-invasive control)

Glass ionomer sealant (with fluoride gel plus dentifrice) showed no clear difference in caries (lesion) progression (radiographic) compared with fluoride gel plus fluoride toothpaste/dentifrice (non-invasive…; GRADE not reported.

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 36 months (radiographic follow-up) · Glass ionomer sealant
  OR 0.13 [0.01, 2.52]
  1 study
  GRADE not reported

Adhesive/polyurethane sealant patch vs No treatment (both arms received flossing plus fluoride toothpaste)

Adhesive/polyurethane sealant patch showed no clear difference in caries (lesion) progression (radiographic) compared with no treatment (both arms received flossing plus fluoride toothpaste); GRADE not reported.

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 36 months (radiographic follow-up) · Sealant patch
  OR 1.00 [0.14, 7.23]
  1 study
  GRADE not reported

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

Micro-invasive treatment (proximal sealing or resin infiltration):… probably leads to lower caries (lesion) progression measured by pairwise reading of… compared with non-invasive measures (e.g. fluoride varnish, flossing/oral hygiene… (moderate certainty).

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  18 to 36 months (radiographic follow-up)
  OR 0.31 [0.18, 0.53]
  4 studies
  Moderate
• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 36 months (radiographic follow-up)
  OR 0.24 [0.14, 0.41]
  7 studies · 365 participants
  Moderate
• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 18 months (radiographic follow-up)
  OR 0.18 [0.06, 0.50]
  3 studies
  Moderate

Resin sealant (one micro-invasive treatment) vs Resin infiltration alone

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  up to 3 years
  Only one study (Martignon 2012) directly compared resin sealant versus resin infiltration; the review could not determine which technique is more advantageous and reported no direct effect estimate for this comparison.
  1 study
  GRADE not reported

Resin sealant (with or without flossing advice) vs Flossing advice (non-invasive control)

Resin sealant (with or without flossing advice) led to lower caries (lesion) progression (radiographic) compared with flossing advice (non-invasive control); GRADE not reported.

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 36 months (radiographic follow-up) · Resin sealant
  OR 0.33 [0.18, 0.59]
  2 studies
  GRADE not reported

Resin infiltration vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Resin infiltration led to lower caries (lesion) progression (radiographic) compared with fluoride varnish, sham/placebo, or flossing advice (non-invasive…; GRADE not reported.

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  12 to 36 months (radiographic follow-up) · Resin infiltration
  OR 0.19 [0.08, 0.46]
  2 studies
  GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes

  15 months
  PF 0.65 [0.12, 1.18]
  1 study · 60 participants
  Low

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes
  Worthington 2001 found no change in reported dental visits over the course of the programmes, with 97% of children at baseline reporting visiting the dentist every 2 years.
  1 study
  GRADE not reported

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

• Primary school‐based behavioural interventions for preventing caries 2013 · Cochrane All outcomes

  2 years
  PF 0.49
  1 study
  GRADE not reported

Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish

The review found no eligible studies for this question.

• Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults 2024 · Cochrane All outcomes
  No studies reported data for this outcome in this comparison
  0 studies
  No studies found

Silver diamine fluoride (SDF) vs Glass ionomer cement (GIC) plus fluoride varnish

The review found no eligible studies for this question.

• Topical silver diamine fluoride (SDF) for preventing and managing dental caries in children and adults 2024 · Cochrane All outcomes
  No studies reported data for this outcome in this comparison
  0 studies
  No studies found