Findings

What do systematic reviews say?

1,163 questions · 1,209 findings · 133 reviews · Headline outcomes only

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No studies found 176 · 14.6%GRADE not reported 47 · 3.9%Very low 241 · 19.9%Low 323 · 26.7%Moderate 315 · 26.1%High 107 · 8.9%

Corticosteroids vs control

Fitness to return to work at 12 months · adults with acute respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological agents for adults with acute respiratory distress syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs promethazine

Severe nausea 48 hours · Pregnant women with hyperemesis gravidarum

Corticosteroids may leads to higher severe nausea 48 hours compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 2 [1.08, 3.72]
1 study · 80 participants
Low

Corticosteroids vs promethazine

Severe nausea 17th day · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes severe nausea 17th day compared with promethazine (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.81 [0.58, 1.15]
1 study · 78 participants
Very low

Corticosteroids vs promethazine

Vomiting · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes episodes of vomiting 48 hours compared with promethazine (very low certainty).

2 findings from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 3 [0.33, 27.63]
1 study · 80 participants
Very low
Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 1 [0.21, 4.65]
1 study · 78 participants
Very low

Corticosteroids vs promethazine

Intervention side effects: drowsiness 48hrs and 3‐10 days · Pregnant women with hyperemesis gravidarum

Corticosteroids showed no clear difference in intervention side effects: drowsiness 48hrs and 3‐10 days compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.08 [0, 1.32]
1 study · 80 participants
Low

Corticosteroids vs promethazine

Perinatal mortality · Pregnant women with hyperemesis gravidarum

Corticosteroids showed no clear difference in stillbirth and neonatal death compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 3 [0.13, 69.52]
1 study · 40 participants
Low

Corticosteroids vs promethazine

Preterm birth · Pregnant women with hyperemesis gravidarum

Corticosteroids showed no clear difference in preterm birth compared with promethazine (low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 3 [0.13, 69.52]
1 study · 40 participants
Low

Corticosteroids vs promethazine

Duration of hospital admission (days) · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo

Length of hospital stay · Pregnant women with hyperemesis gravidarum

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 110 participants
Very low

Corticosteroids vs placebo

Pregnancy complications · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes pregnancy complications compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.61 [0.26, 1.47]
1 study · 110 participants
Very low

Corticosteroids vs placebo

Spontaneous abortion · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes spontaneous abortion compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.64 [0.11, 3.7]
1 study · 110 participants
Very low

Corticosteroids vs placebo

Perinatal mortality · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes stillbirth and neonatal death compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.7 [0.15, 3.34]
2 studies · 134 participants
Very low

Corticosteroids vs placebo

Congenital abnormalities · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes congenital abnormalities compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.73]
1 study · 110 participants
Very low

Corticosteroids vs placebo

Side effects · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes intervention side effects compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 0.79 [0.06, 11.2]
1 study · 25 participants
Very low

Corticosteroids vs placebo

Preterm birth · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes preterm birth compared with placebo (very low certainty).

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
RR 1.01 [0.31, 3.28]
2 studies · 134 participants
Very low

Corticosteroids vs placebo

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Quality of life outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Corticosteroids vs placebo compared

Death ‐ at 180 days after ICU admission, in total population randomised · critically ill patients

Corticosteroids showed no clear difference in death ‐ death at 180 days in total population randomised compared with placebo compared (high certainty).

1 finding from 1 review

Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
RR 0.99 [0.64, 1.52]
1 study · 180 participants
High

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ shock · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ shock compared with placebo compared (high certainty).

1 finding from 1 review

Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
RR 0.41 [0.17, 1.01]
1 study · 180 participants
High

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ serious infection · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ serious infection compared with placebo compared (high certainty).

1 finding from 1 review

Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
RR 0.68 [0.42, 1.11]
1 study · 180 participants
High

Corticosteroids vs placebo compared

Serious adverse events (dichotomous data) ‐ suspected or probable pneumonia · critically ill patients

Corticosteroids showed no clear difference in serious adverse events (dichotomous data) ‐ suspected or probable… compared with placebo compared (high certainty).

1 finding from 1 review

Interventions for preventing critical illness polyneuropathy and critical illness myopathy 2014 · Cochrane Headline outcomes only
RR 0.44 [0.18, 1.09]
1 study · 180 participants
High