Findings

What do systematic reviews say?

406 questions · 416 findings · 20 reviews · Common Mental Disorders

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No studies found 73 · 17.5%GRADE not reported 9 · 2.2%Very low 144 · 34.6%Low 123 · 29.6%Moderate 59 · 14.2%High 8 · 1.9%

Abrupt discontinuation vs continuation of long‐term antidepressants

Relapse · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes relapse (as defined by study authors) (HR) compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
HR 2.09 [1.59, 2.74]
10 studies · 1373 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Adverse events · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 690 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Depressive symptoms · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 484 participants
Low

Discontinuation with high‐intensity psychological interventions vs continuation

Anxiety · participants with long‐term antidepressants for depressive disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

Quality of life · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 455 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Social and occupational functioning · participants with long‐term antidepressants for depressive disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Relapse · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Withdrawal symptoms · participants with long‐term antidepressants for depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Adverse events · participants with long‐term antidepressants for depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Depressive symptoms · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 106 participants
Low

Abrupt discontinuation vs continuation of long‐term antidepressants

Withdrawal symptoms · participants with depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 182 participants
Very low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Anxiety · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 104 participants
Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Quality of life · participants with long‐term antidepressants for depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 146 participants
Very low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Social and occupational functioning · participants with long‐term antidepressants for depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

Adverse events · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
OR 1.11 [0.62, 1.99]
7 studies · 1012 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Depressive symptoms · participants with depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 330 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Anxiety · participants with depressive or anxiety disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 439 participants
Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

Quality of life · participants with depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

Social and occupational functioning · participants with depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Exercise therapy vs antidepressants

FatigueMeasured at end of treatment, 26 weeks · men and women aged over 18 years with chronic fatigue syndrome

1 finding from 1 review

Exercise therapy for chronic fatigue syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 48 participants
Very low