Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Sunscreen vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis

It is very uncertain whether sunscreen changes incidence of herpes labialis during use of the preventative… compared with placebo (very low certainty).

2 findings from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Interferon vs placebo

Adverse effects during use of the preventative intervention (fever) ‐ pre‐ and postsurgical · participants with recurrent herpes labialis

Interferon showed no clear difference in adverse effects during use of the preventative intervention (fever)… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 400 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (low certainty).

1 finding from 1 review

Gamma‐globulin vs histamine (control)

Severity of attack of recurrent herpes labialis during use of the preventative intervention (less severe recurrences than usual) · participants with recurrent herpes labialis

Gamma globulin showed no clear difference in severity of attack of recurrent herpes labialis during use of the… compared with histamine (control) (low certainty).

1 finding from 1 review

Oral aciclovir (long‐term) vs placebo

Incidence of herpes labialis during use of the preventative intervention · participants with recurrent herpes labialis
2 findings from 1 review