What do systematic reviews say?

Summary of findings ‐ monotherapy: lumacaftor vs placebo

The review found no eligible studies for this question.

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ dual therapy: tezacaftor plus ivacaftor vs placebo or ivacaftor alone

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 944 participants
  Low

Summary of findings ‐ triple therapy: VX‐659‐tezacaftor‐ivacaftor/deutivacaftor vs control

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  6 participants
  GRADE not reported

Summary of findings ‐ triple therapy: VX‐659‐tezacaftor‐ivacaftor/deutivacaftor vs control

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 382 participants
  Moderate

Summary of findings ‐ monotherapy: lumacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 61 participants
  Moderate

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor/deutivacaftor vs control

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 603 participants
  Moderate

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor/deutivacaftor vs control

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 578 participants
  Moderate

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor vs control (ivacaftor alone or tezacaftor plus ivacaftor)

The review found no eligible studies for this question.

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ triple therapy: elexacaftor‐tezacaftor‐ivacaftor vs control (ivacaftor alone or tezacaftor plus ivacaftor)

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 258 participants
  Moderate

Summary of findings ‐ triple therapy: VX‐440‐tezacaftor‐ivacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low

Summary of findings ‐ triple therapy: VX‐440‐tezacaftor‐ivacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Low

Summary of findings ‐ triple therapy: VX‐152‐tezacaftor‐ivacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  Low

Summary of findings ‐ triple therapy: VX‐152‐tezacaftor‐ivacaftor vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 76 participants
  Low

Summary of findings table ‐ DMT vs waiting list control

• Dance movement therapy for dementia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 137 participants
  Low

Summary of findings table ‐ DMT vs exercise

• Dance movement therapy for dementia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 136 participants
  Low

Mobile phone interventions vs usual care

Summary of findings table ‐ Mobile phone‐based interventions showed no clear difference in pregnancy compared with standard of care (moderate certainty).

• Mobile phone‐based interventions for improving contraception use 2023 · Cochrane Headline outcomes only
  OR 0.82 [0.48, 1.38]
  8 studies · 2947 participants
  Moderate

Intervention not reported

It is very uncertain whether the intervention changes pregnancy rate (clinical or positive urine pregnancy test) (very low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  RR 1.08 [0.89, 1.3]
  3 studies · 262 participants
  Very low

Intervention not reported

The intervention showed no clear difference in time to pregnancy (low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  HR 0.86 [0.53, 1.38]
  1 study · 140 participants
  Low

Intervention not reported

The intervention showed no clear difference in clinical pregnancy rate (low certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  RR 1.09 [0.51, 2.31]
  1 study · 148 participants
  Low

Intervention not reported

The intervention probably leads to higher pregnancy rate(clinical pregnancy or urine pregnancy test) (moderate certainty).

• Timed intercourse for couples trying to conceive 2023 · Cochrane Headline outcomes only
  RR 1.28 [1.09, 1.5]
  4 studies · 2202 participants
  Moderate