Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Resin-based fissure sealant vs Fluoride varnish

Change in DMFS (decayed, missing and filled permanent surfaces) increment · Children and adolescents (general population, aged under 20 years)

Resin-based fissure sealant led to lower change in DMFS (decayed, missing and filled permanent surfaces)… compared with fluoride varnish; GRADE not reported.

1 finding from 1 review

Surgical removal (extraction) of asymptomatic disease-free impacted wisdom teeth vs Retention (conservative management) of asymptomatic disease-free impacted wisdom teeth

Intercanine width · Adolescents or adults with asymptomatic disease-free impacted wisdom teeth

Surgical removal (extraction) of asymptomatic disease-free impacted… showed no clear difference in intercanine width (dimensional changes in the dental arch) compared with retention (conservative management) of asymptomatic disease-free… (low certainty).

1 finding from 1 review

Blue fluorescence devices (VistaProof, SoproLife, Spectra; wavelength 400-450 nm) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic odds ratio (DOR) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

All fluorescence-based devices (red, blue, and green fluorescence combined) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic odds ratio (DOR) by subgroup: High dentine-caries prevalence (>=35%) (detection of early enamel caries, D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review

Pre-cooling of the injection site vs Conventional treatment

Successful LA/painless treatment · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Lingual nerve retractor (subperiosteal or Free's) vs No retractor

Permanent altered tongue, chin, or lip sensation · Adults with mandibular third molars requiring removal

It is very uncertain whether lingual nerve retractor (subperiosteal or Free's) changes permanent altered tongue, chin, or lip sensation compared with no retractor (very low certainty).

1 finding from 1 review

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care vs placebo or usual care

Duration of systemic antibiotic use · Critically ill patients (adults and children) receiving mechanical ventilation in ICU

Chlorhexidine (mouthrinse or gel), as part of oral hygiene care showed no clear difference in duration of systemic antibiotic use compared with placebo or usual care; GRADE not reported.

1 finding from 1 review

Topical triamcinolone acetonide vs pimecrolimus 1%

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean VAS score) compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review

Video modelling acclimatisation vs Acclimatisation in clinic (tell-show-do)

Patient satisfaction: measured by questionnaires · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Camouflage syringe vs Conventional syringe

Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Antimicrobial mouthwash and/or nasal spray (alone or in combination), any concentration, frequency or dosage vs No treatment or saline or water

Changes in microbiome in oral cavity, nasal cavity, oro- or nasopharynx · Patients with suspected or confirmed COVID-19 infection

The review found no eligible studies for this question.

1 finding from 1 review

Clinical examination with risk-based recall vs Clinical examination with 24-month recall

Dental caries: prevalence of root caries · Dentate adults (aged 18 years and older) receiving dental check-ups in UK general dental practices (regular attenders)

Clinical examination with risk-based recall showed no clear difference in dental caries: prevalence of root caries compared with clinical examination with 24-month recall; GRADE not reported.

1 finding from 1 review

Rubber dam + HVE vs Cotton roll + HVE

Reduction in level of contamination in aerosols (CFU) during restorative procedures at dental unit light · People undergoing aerosol-generating procedures (AGPs) in a dental setting

It is very uncertain whether rubber dam + HVE changes reduction in level of contamination in aerosols (CFU) during… compared with cotton roll + HVE (very low certainty).

1 finding from 1 review