Findings

What do systematic reviews say?

4,587 questions · 5,761 findings · 495 reviews

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No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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Oral retinoids: alitretinoin 10 mg vs placebo

Primary: participant‐rated good/excellent control of symptoms · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 10 mg leads to higher primary: participant‐rated good/excellent control of symptoms compared with placebo (high certainty).

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
RR 1.73 [1.25, 2.4]
2 studies · 765 participants
High

Oral retinoids: alitretinoin 10 mg vs placebo

Primary outcome 3: Adverse events · people with moderate to severe chronic hand eczema

Oral retinoids: alitretinoin 10 mg showed no clear difference in primary: all adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
RR 1.01 [0.66, 1.55]
1 study · 158 participants
Moderate

Oral retinoids: alitretinoin 10 mg vs placebo

Secondary: investigator‐rated reduction in severity of TLSSd · people with moderate to severe chronic hand eczema

1 finding from 1 review

Interventions for hand eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 158 participants
Moderate

Oral irrigation plus toothbrushing vs Flossing plus toothbrushing

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether oral irrigation plus toothbrushing changes plaque compared with flossing plus toothbrushing (very low certainty).

1 finding from 1 review

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
1 month
SMD 0.31 [-0.08, 0.70]
2 studies · 133 participants
Very low

Oral irrigation plus toothbrushing vs Toothbrushing alone

Interproximal caries · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
No included study assessed caries as an outcome.
0 studies
No studies found

Oral irrigation plus toothbrushing vs Flossing plus toothbrushing

Interproximal caries · Adults, 16 years and older (dentate)

The review found no eligible studies for this question.

1 finding from 1 review

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
No included study assessed caries as an outcome.
0 studies
No studies found

Oral irrigation plus toothbrushing vs Flossing plus toothbrushing

Side effects · Adults, 16 years and older (dentate)

1 finding from 1 review

Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal… 2019 · Cochrane All outcomes
Both studies reported that there were no adverse events in either study group.
2 studies
GRADE not reported

Intermittent oral or rectal diazepam vs placebo or no treatment

Recurrent seizure at 6 months · children with febrile seizures

Intermittent oral or rectal diazepam probably leads to lower recurrent seizure at 6 months compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.64 [0.48, 0.85]
6 studies · 1151 participants
Moderate

Intermittent oral or rectal diazepam vs placebo or no treatment

Recurrent seizure at 12 months · children with febrile seizures

Intermittent oral or rectal diazepam probably leads to lower recurrent seizure at 12 months compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.69 [0.56, 0.84]
8 studies · 1416 participants
Moderate

Intermittent oral or rectal diazepam vs placebo or no treatment

Recurrent seizure at 18 months · children with febrile seizures

Intermittent oral or rectal diazepam may leads to lower recurrent seizure at 18 months compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.37 [0.23, 0.6]
1 study · 289 participants
Low

Intermittent oral or rectal diazepam vs placebo or no treatment

Recurrent seizure at 24 months · children with febrile seizures

Intermittent oral or rectal diazepam leads to lower recurrent seizure at 24 months compared with placebo or no treatment (high certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.73 [0.56, 0.95]
4 studies · 739 participants
High

Intermittent oral or rectal diazepam vs placebo or no treatment

Recurrent seizure at 36 months · children with febrile seizures

Intermittent oral or rectal diazepam may leads to lower recurrent seizure at 36 months compared with placebo or no treatment (low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.58 [0.4, 0.85]
1 study · 139 participants
Low

Intermittent oral or rectal diazepam vs placebo or no treatment

Recurrent seizure at 48 months · children with febrile seizures

Intermittent oral or rectal diazepam probably leads to lower recurrent seizure at 48 months compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.36 [0.15, 0.89]
1 study · 110 participants
Moderate

Intermittent oral or rectal diazepam vs placebo or no treatment

Recurrent seizure at 60 months or greater · children with febrile seizures

It is very uncertain whether intermittent oral or rectal diazepam changes recurrent seizure at 60 months or greater compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.08 [0, 1.31]
1 study · 60 participants
Very low

Oral miltefosine (50 mg for 28 days) vs 28 days on/off placebo regimen

Complete cure, at least 3 months after the end of treatment · People with American cutaneous and mucocutaneous leishmaniasis

Oral miltefosine (50 mg for 28 days) probably leads to higher complete cure, at least 3 months after the end of treatment compared with placebo (same regimen) (moderate certainty).

1 finding from 1 review

Interventions for American cutaneous and mucocutaneous leishmaniasis 2020 · Cochrane Headline outcomes only
RR 2.25 [1.42, 3.38]
1 study · 133 participants
Moderate

Oral miltefosine (50 mg for 28 days) vs 28 days on/off placebo regimen

Adverse effects (number of participants who had the event) · People with American cutaneous and mucocutaneous leishmaniasis

Oral miltefosine (50 mg for 28 days) probably leads to higher adverse effects (number of participants who had the event) compared with placebo (same regimen) (moderate certainty).

1 finding from 1 review

Interventions for American cutaneous and mucocutaneous leishmaniasis 2020 · Cochrane Headline outcomes only
RR 3.96 [1.49, 10.48]
1 study · 133 participants
Moderate

Oral miltefosine (50 mg for 28 days) vs 28 days on/off placebo regimen

Recurrence · People with American cutaneous and mucocutaneous leishmaniasis

Oral miltefosine (50 mg for 28 days) showed no clear difference in recurrence compared with placebo (same regimen) (low certainty).

1 finding from 1 review

Interventions for American cutaneous and mucocutaneous leishmaniasis 2020 · Cochrane Headline outcomes only
RR 2.97 [0.37, 23.89]
1 study · 133 participants
Low

Summary of findings: oral β‐carotene vs placebo

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Very low

Summary of findings: oral β‐carotene vs placebo

Quality of life · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: oral β‐carotene vs placebo

Change in BMI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found