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Evidence found and GRADE certainty

2,066 questions · 3,346 findings · 178 reviews · Dental caries

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No studies found 48 · 1.4%GRADE not reported 2,789 · 83.4%Very low 208 · 6.2%Low 129 · 3.9%Moderate 136 · 4.1%High 36 · 1.1%

TT genotype of AMELX rs17878486 vs CC genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs17878486 and dental caries susceptibility (TT vs CC model: OR 5.12, 95% CI 0.09-278.85) in the Control group: Caries-free subgroup; certainty not graded.

8 findings from 1 review
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Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Caries incidence (proportion of enrolled children developing dentin caries, ICDAS 4-6) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

Fluoride varnish and fissure sealant did not differ significantly in the proportion of children developing caries at 2 to 3 years (RR 1.12, 95% CI 0.60 to 2.09; 2 RCTs; ungraded).

1 finding from 1 review

CT + TT genotype (T-allele carriers) of AMELX rs2106416 vs CC genotype of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs2106416 and dental caries susceptibility (CT + TT vs CC model: OR 0.59, 95% CI 0.15-2.31) in the Age group: Children subgroup; certainty not graded.

3 findings from 1 review

G allele of LTF rs1126478 vs A allele of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between G allele vs A allele of LTF rs1126478 and dental caries susceptibility (G vs A model: OR 0.98, 95% CI 0.87-1.10); certainty not graded.

5 findings from 1 review
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T allele of AMELX rs17878486 vs C allele of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of AMELX rs17878486 and dental caries susceptibility (T vs C model: OR 2.87, 95% CI 0.35-23.23) in the Control group: Caries-free subgroup; certainty not graded.

8 findings from 1 review
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CT genotype of AMELX rs2106416 vs CC genotype of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (CT vs CC model: OR 1.20, 95% CI 0.65-2.22) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review

GG genotype of ENAM rs1264848 vs AA + AG genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA + AG genotype of ENAM rs1264848 and dental caries susceptibility (GG vs AA + AG model: OR 1.09, 95% CI 0.53-2.23) in the Ethnicity: Mixed subgroup; certainty not graded.

6 findings from 1 review
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