Adverse events · Children with a non-nutritive sucking habit (digit or pacifier)
1 finding from 1 review
Sucking cessation (long term) · Children with a non-nutritive sucking habit (digit or pacifier)
Orthodontic appliances (palatal crib) led to higher sucking cessation (long term) compared with no treatment; GRADE not reported.
1 finding from 1 review
Oral mucositis (severe) · All patients with cancer who are receiving treatment
Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… probably leads to lower oral mucositis (severe) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (moderate certainty).
3 findings from 1 review
RR 0.38 [0.20, 0.72]
5 studies · 270 participants
Moderate
RR 0.88 [0.61, 1.25]
1 study · 122 participants
Very low
RR 0.40 [0.27, 0.61]
5 studies · 444 participants
Moderate
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.2); 81 participants in…
1 study · 81 participants
GRADE not reported
Sucking cessation (short term) · Children with a non-nutritive sucking habit (digit or pacifier)
It is very uncertain whether palatal arch changes sucking cessation (short term) compared with palatal crib (alternative orthodontic appliance) (very low certainty).
1 finding from 1 review
Number of days of treatment with opioid analgesics · All patients with cancer who are receiving treatment
The review found no eligible studies for this question.
2 findings from 1 review
Disease-free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
It is very uncertain whether non-specific immunotherapy (recombinant interleukin-2 or BCG cell… changes disease-free survival compared with standard therapy alone (very low certainty).
1 finding from 1 review
Progression‐free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
EGFR monoclonal antibody (cetuximab or nimotuzumab) plus standard… showed no clear difference in progression-free survival compared with standard therapy alone (radiotherapy or chemoradiotherapy); GRADE not reported.
2 findings from 1 review
Quality of life · All patients with cancer who are receiving treatment
2 findings from 1 review
Summary of findings 2 (melphalan/HSCT): Quality of life - '1 study assessed this outcome but the data are currently unavailable as the study report and analysis have not yet been completed' (Toro 2013; measured with…
1 study
GRADE not reported
Summary of findings for the main comparison (5FU solid cancers): Quality of life - 'No studies assessed this outcome'.
0 studies
No studies found
Pacifier withdrawal vs No treatment
Outcome not reported · Children with a non-nutritive sucking habit (digit or pacifier)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · All patients with cancer who are receiving treatment
2 findings from 1 review
Adverse events reported narratively: one study did not report adverse events (Askarifar 2015); another reported no serious adverse events (Toro 2013); the remaining two reported low rates of shooting pain from the…
3 studies
GRADE not reported
Adverse events reported narratively (not meta-analysed): one study reported no adverse effects (Katranci 2012); the other four 5FU studies reported low rates of very minor adverse events (headache, chills,…
5 studies · 444 participants
GRADE not reported
Oral mucositis (severe) · Patients with osteosarcoma (bone cancer) receiving high-dose methotrexate, vincristine and leucovorin
1 finding from 1 review
Oral mucositis (severe). Not estimable - no participants had developed severe oral mucositis by the fourth day after chemotherapy when the data were reported (Zhang 2011, Analysis 4.3, subgroup 3.1); 118 participants…
1 study · 118 participants
GRADE not reported
Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…
Glass ionomer sealant (with fluoride gel plus dentifrice) showed no clear difference in caries (lesion) progression (radiographic) compared with fluoride gel plus fluoride toothpaste/dentifrice (non-invasive…; GRADE not reported.
1 finding from 1 review
OR 0.13 [0.01, 2.52]
1 study
GRADE not reported
Progression‐free survival · People with squamous cell carcinoma of the oral cavity or oropharynx
It is very uncertain whether tyrosine kinase inhibitor (erlotinib, gefitinib or lapatinib) plus… changes progression-free survival compared with standard therapy alone (radiotherapy or chemoradiotherapy) (very low certainty).
1 finding from 1 review
Participant satisfaction · People with squamous cell carcinoma of the oral cavity or oropharynx
The review found no eligible studies for this question.
1 finding from 1 review
Sucking cessation (short term) · Children with a non-nutritive sucking habit (digit or pacifier)
Orthodontic appliances (palatal arch/palatal crib) may leads to higher sucking cessation (short term) compared with no treatment (low certainty).
1 finding from 1 review
Occlusion (net change in overjet, short term) · Children with a non-nutritive sucking habit (digit or pacifier)
1 finding from 1 review
Table 1 (reduction in malocclusion), Villa 1997 (n=24), palatal crib vs no treatment: net change in overjet (mm) - no treatment 0.02; palatal crib -0.2; no statistically significant net change in overjet between…
1 study · 24 participants
GRADE not reported
Oral mucositis (mean severity on WHO 0 to 4 scale) · All patients with cancer who are receiving treatment
It is very uncertain whether oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed… changes oral mucositis (mean severity on WHO 0 to 4 scale) compared with control (no treatment or standard/usual oral care, e.g. saline rinse) (very low certainty).
1 finding from 1 review
Costs (direct and indirect) · People with squamous cell carcinoma of the oral cavity or oropharynx
The review found no eligible studies for this question.
1 finding from 1 review
Root canal medications and canal filling, splinting, extraction of teeth, or surgical removal of any relevant pathology vs Each other, placebo, or no treatment
Outcome not reported · Patients with single and multiple permanent teeth with evidence of any type of external root resorption irrespective of its aetiology,…
The review found no eligible studies for this question.
1 finding from 1 review
None of the studies fulfilled our inclusion criteria and therefore no data analysis was conducted. (Main results: no RCTs that met the inclusion criteria were identified; one ongoing study, NCT00423956, potentially…
0 studies
No studies found