Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,760 questions · 8,065 findings · 1,036 reviews

No studies found 1,686 · 20.9%GRADE not reported 675 · 8.4%Very low 1,953 · 24.2%Low 2,048 · 25.4%Moderate 1,296 · 16.1%High 407 · 5%

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Altered WBRT fractionation schedules vs WBRT control

Overall survival: higher‐dose WBRT vs control (3000 cGy/10 daily fractions)No. of participants: 846(4 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules probably leads to higher overall survival: lower‐dose WBRT vs control WBRT (3000 cGy/10 daily… compared with WBRT control (moderate certainty).

1 finding from 1 review

Altered WBRT fractionation schedules vs WBRT control: neurological function improvement

Neurological function improvement: lower‐dose WBRT vs control dose WBRT (3000 cGy/10 fractions)No. of participants: 1612(5 RCTs) · patients with newly diagnosed multiple brain metastases

Altered WBRT fractionation schedules probably leads to higher neurological function improvement: lower‐dose WBRT vs control dose… compared with WBRT control: neurological function improvement (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain: 50% reduction in headache frequency Post‐treatment Lower scores = fewer headaches · Children and adolescents with chronic pain

It is very uncertain whether the intervention changes pain: 50% reduction in headache frequency Post‐treatment Lower… (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Any cancer risk No. of participants: 19,475 (3 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in any cancer risk No. of participants: 19,475 (3 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Cancer mortality risk No. of participants: 17,448 (1 RCT) · Participants in trials with low risk of bias

Highest showed no clear difference in cancer mortality risk No. of participants: 17,448 (1 RCT) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Colorectal cancer risk (16 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in colorectal cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Non‐melanoma skin cancer risk No. of participants: 2027 (2 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in non‐melanoma skin cancer risk No. of participants: 2027 (2 RCTs) compared with lowest selenium exposure (moderate certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in lung cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in breast cancer risk No. of participants: 802 (1 RCT) compared with lowest selenium exposure (moderate certainty).

1 finding from 1 review