What do systematic reviews say?

Abrupt discontinuation vs continuation of long‐term antidepressants

It is very uncertain whether abrupt discontinuation changes relapse (as defined by study authors) (HR) compared with continuation of long‐term antidepressants (very low certainty).

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  HR 2.09 [1.59, 2.74]
  10 studies · 1373 participants
  Very low

Discontinuation with high‐intensity psychological interventions vs continuation

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 690 participants
  Very low

Discontinuation with high‐intensity psychological interventions vs continuation

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 484 participants
  Low

Discontinuation with high‐intensity psychological interventions vs continuation

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation with high‐intensity psychological interventions vs continuation

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 455 participants
  Very low

Discontinuation with high‐intensity psychological interventions vs continuation

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 182 participants
  Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  OR 1.11 [0.62, 1.99]
  7 studies · 1012 participants
  Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 330 participants
  Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 439 participants
  Very low

Abrupt discontinuation vs continuation of long‐term antidepressants

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Abrupt discontinuation vs continuation of long‐term antidepressants

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Single‐component hydration intervention vs control

The review found no eligible studies for this question.

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multicomponent educational intervention vs control

The review found no eligible studies for this question.

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multicomponent educational intervention vs control

Multicomponent educational intervention showed no clear difference in mortality compared with control (moderate certainty).

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  RR 0.82 [0.5, 1.34]
  1 study · 215 participants
  Moderate

Multicomponent educational intervention vs control

The review found no eligible studies for this question.

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multicomponent educational intervention vs control

The review found no eligible studies for this question.

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Multicomponent educational intervention vs control

Multicomponent educational intervention probably leads to lower hospital admissions compared with control (moderate certainty).

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  RR 0.67 [0.57, 0.79]
  1 study · 494 participants
  Moderate

Single‐component medication monitoring and adjustment intervention vs control

The review found no eligible studies for this question.

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Single‐component medication monitoring and adjustment intervention vs control

Single‐component medication monitoring and adjustment intervention probably leads to lower incidence of delirium NH‐CAM compared with control (moderate certainty).

• Interventions for preventing delirium in older people in institutional long‐term care 2019 · Cochrane Headline outcomes only
  HR 0.42 [0.34, 0.51]
  1 study · 7311 participants
  Moderate