Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Intravenous ketorolac vs placebo

Use of rescue medication · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

It is very uncertain whether intravenous ketorolac changes number of participants using rescue medication over 4 or 6 hours… compared with placebo (very low certainty).

1 finding from 1 review

Intravenous ketorolac vs placebo

Number of participants reporting an adverse event · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants reporting any adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Intravenous ketorolac vs placebo

Number of participants experiencing any serious adverse events · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants experiencing a serious adverse event compared with placebo (low certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Participant‐reported pain relief of 50% or greater · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants with at least 50% pain relief over 4 hours compared with another NSAID (low certainty).

1 finding from 1 review

Intravenous ketorolac vs NSAIDs

Relief of pain · adults (mean study ages 23 to 67 years) with acute postoperative pain after abdominal/pelvic, dental or orthopedic surgeries

Intravenous ketorolac showed no clear difference in number of participants with at least 50% pain relief over 6 hours compared with another NSAID (moderate certainty).

1 finding from 1 review

Screws vs fixed angle plates

Mobility · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether screws changes mobility: walking as before fracture, or using 1 walking stick now… compared with fixed angle plates (very low certainty).

1 finding from 1 review

Screws vs fixed angle plates

Mortality: early (within 4 months) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

It is very uncertain whether screws changes mortality: early (within 4 months) compared with fixed angle plates (very low certainty).

1 finding from 1 review

Screws vs fixed angle plates

Mortality at 12 months (Data prioritised at 12 months, but in its absence we included data after 4 months and up to 24 months.) · older adults (> 60 years of age) with intracapsular hip fractures; most fractures in the included studies were displaced

Screws showed no clear difference in mortality at 12 months (Data prioritised at 12 months, but in its… compared with fixed angle plates (low certainty).

1 finding from 1 review