Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,793 questions · 1,866 findings · 339 reviews

No studies found 245 · 13.1%GRADE not reported 142 · 7.6%Very low 612 · 32.8%Low 513 · 27.5%Moderate 305 · 16.3%High 49 · 2.6%

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

High‐grade cervical, vulval, vaginal, penile, or anal intraepithelial neoplasia · 9‐ to 14‐year‐old females and males

The review found no eligible studies for this question.

1 finding from 1 review

Two doses of HPV vaccine with longer interval vs two doses of HPV vaccine with shorter interval

Serious adverse events at up to 5‐year · 9‐ to 14‐year‐old females and males

It is very uncertain whether two doses of HPV vaccine with longer interval changes serious adverse events at up to 5‐year compared with two doses of HPV vaccine with shorter interval (very low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Hepatotoxicity · people with paracetamol (acetaminophen) overdose

It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics from 0‐2 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics from 0‐2 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics 0‐12 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics 0‐12 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Anaphylactoid symptoms · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower anaphylactoid symptoms compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

RISPERIDONE vs OLANZAPINE

Leaving the study early · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes leaving study early: any reason compared with OLANZAPINE ‒ short‐ and long‐term data (very low certainty).

1 finding from 1 review

RISPERIDONE vs QUETIAPINE

Leaving the study early · people with both severe mental illness and substance misuse

RISPERIDONE showed no clear difference in leaving the study early: 1. any reason, long term (>12 months) compared with QUETIAPINE ‒ short‐ and long‐term data (low certainty).

1 finding from 1 review

RISPERIDONE vs CLOZAPINE ‐ all data short term

Substance use: improvement ‒ (at least 20% reduction in use, TLFB scale) · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes substance use: improvement ‒ (at least 20% reduction in use, TLFB… compared with CLOZAPINE ‐ all data short term (very low certainty).

1 finding from 1 review