Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Insulin vs placebo

FEV1 % predicted: absolute change from baseline · adults with CFRD

Summary of findings: insulin showed no clear difference in FEV1 % predicted: change from baseline compared with placebo (low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
MD 1.2
1 study · 39 participants
Low

Summary of findings: NPH insulin vs insulin glargine

Hypoglycemia mean number of events per participant · adults with CFRD and fasting hyperglycemia

It is very uncertain whether summary of findings: NPH insulin changes hypoglycemia mean number of events per participant compared with glargine (very low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Insulin vs placebo

FVC (% predicted) Change from baseline · adults with CFRD

Summary of findings: insulin showed no clear difference in FVC % predicted: change from baseline compared with placebo (low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
MD 0.6
1 study · 39 participants
Low

Insulin vs placebo

Change in BMI · adults with CFRD

Summary of findings: insulin showed no clear difference in BMI(kg/m²): change from baseline compared with placebo (low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
MD 0.41
1 study · 39 participants
Low

Insulin vs placebo

Hypoglycemia: number of episodes · adults with CFRD

Summary of findings: insulin showed no clear difference in hypoglycemia: number of episodes compared with placebo (low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
RR 9.23 [0.53, 159.14]
1 study · 55 participants
Low

Summary of findings: repaglinide vs placebo

HbA1c (%) · adults with CFRD

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Very low

Summary of findings: repaglinide vs placebo

FEV1 (% predicted): mean change from baseline · adults with CFRD

Summary of findings: repaglinide showed no clear difference in FEV1 % predicted; change from baseline compared with placebo (low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
MD 1.7
1 study · 38 participants
Low

Summary of findings: repaglinide vs placebo

FVC (% predicted) Change from baseline · adults with CFRD

Summary of findings: repaglinide showed no clear difference in FVC % predicted: change from baseline compared with placebo (low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 38 participants
Low

Summary of findings: repaglinide vs placebo

Change in BMI · adults with CFRD

Summary of findings: repaglinide showed no clear difference in BMI (kg/m²): change from baseline compared with placebo (low certainty).

1 finding from 1 review

Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
MD 0.17
1 study · 38 participants
Low

Respiratory muscle training vs control

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Respiratory muscle training for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 83 participants
Very low

Respiratory muscle training vs control

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Respiratory muscle training for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 72 participants
Very low

Respiratory muscle training vs control

Exercise capacity · adults and children with cystic fibrosis

1 finding from 1 review

Respiratory muscle training for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 54 participants
Very low

Respiratory muscle training vs control

HRQoL: total score · adults and children with cystic fibrosis

1 finding from 1 review

Respiratory muscle training for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 69 participants
Very low

Respiratory muscle training vs control

Respiratory muscle function: maximal inspiratory pressure (PImax) · adults and children with cystic fibrosis

1 finding from 1 review

Respiratory muscle training for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 87 participants
Very low

Respiratory muscle training vs control

Respiratory muscle function: inspiratory capacity · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Respiratory muscle training for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oscillating devices vs PEP

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 510 participants
Very low

Oscillating devices vs breathing techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 181 participants
Low

Oscillating devices vs breathing techniques

Sputum: volume · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 14 participants
Low

Oscillating devices vs breathing techniques

Sputum: weight (dry or wet) (g) · adults and children with cystic fibrosis

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 114 participants
Low

Oscillating devices vs breathing techniques

Frequency of exacerbationsb · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found