Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder
Esketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).
1 finding from 1 review
OR 2.11 [1.2, 3.68]
Studies not reported
Low
Remission · adults with Major Depressive Disorder
Esketamine probably leads to higher efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (moderate certainty).
1 finding from 1 review
OR 2.74 [1.71, 4.4]
Studies not reported
Moderate
Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Moderate
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
Esketamine showed no clear difference in acceptability: total dropouts№ of participants: 773(5 RCTs) compared with placebo (moderate certainty).
1 finding from 1 review
OR 1.58 [0.92, 2.73]
Studies not reported
Moderate
Withdrawals due to adverse events · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Remission · adults with Major Depressive Disorder
It is very uncertain whether ketamine changes efficacy: number of participants who achieve remission ‐ at 24 hours… compared with placebo (very low certainty).
1 finding from 1 review
OR 5.6 [1.07, 29.46]
Studies not reported
Very low
Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
It is very uncertain whether ketamine changes acceptability: total dropouts№ of participants: 201(6 RCTs) compared with placebo (very low certainty).
1 finding from 1 review
OR 1.25 [0.19, 8.28]
Studies not reported
Very low
Withdrawals due to adverse events · adults with Major Depressive Disorder
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults with Major Depressive Disorder
It is very uncertain whether ketamine changes efficacy: number of participants who respond to treatment ‐ at 24… compared with midazolam (very low certainty).
1 finding from 1 review
OR 2.48 [1, 6.18]
Studies not reported
Very low
Remission · adults with Major Depressive Disorder
Ketamine showed no clear difference in efficacy: number of participants who achieve remission ‐ at 24 hours compared with midazolam (low certainty).
1 finding from 1 review
OR 2.21 [0.67, 7.32]
Studies not reported
Low
Depressive symptoms · adults with Major Depressive Disorder
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Acceptability ‐ total dropouts · adults with Major Depressive Disorder
Ketamine showed no clear difference in acceptability: total dropouts№ of participants: 72(1 RCT) compared with midazolam (low certainty).
1 finding from 1 review
OR 0.33 [0.05, 2.09]
Studies not reported
Low
Proportion of participants who were medication‐free (not using drops) at 12 months · people with open‐angle glaucoma
It is very uncertain whether phaco‐AIT changes proportion of participants who were medication‐free (not using… compared with phaco‐Trab (very low certainty).
1 finding from 1 review
Mean change in IOP measured in mmHg 12 months postintervention · people with open‐angle glaucoma
1 finding from 1 review
Mean change in number of IOP‐lowering drops from baseline · people with open‐angle glaucoma
1 finding from 1 review
Proportion needing additional glaucoma surgery at 1‐year · people with open‐angle glaucoma
It is very uncertain whether phaco‐AIT changes proportion of participants who required further glaucoma surgery at… compared with phaco‐Trab (very low certainty).
1 finding from 1 review
Rate of visual field progression · people with open‐angle glaucoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mean change in health‐related quality of life · people with open‐angle glaucoma
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intraoperative and postoperative complications · people with open‐angle glaucoma
1 finding from 1 review
no estimate extracted
8 participants
Very low