Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Tetracycline vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Tetracycline vs placebo

Participant‐assessed improvement in rosacea severity · Participants with rosacea

Tetracycline showed no clear difference in participant‐assessed improvement in rosacea severity compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

Proportion of participants with adverse event · Participants with rosacea

Tetracycline showed no clear difference in proportion of participants with adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Tetracycline vs placebo

Physician‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review

Tetracycline vs placebo

Time needed until improvement of the skin lesions · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Tetracycline vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline 40 mg vs placebo

HRQOL ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline 40 mg vs placebo

Participant‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review

Metronidazole vs placebo

Duration of remission · Participants with rosacea

Metronidazole probably leads to lower duration of remission compared with placebo (moderate certainty).

1 finding from 1 review

Doxycycline 40 mg vs placebo

Duration of remission ‐ not measured · Participants with rosacea

The review found no eligible studies for this question.

1 finding from 1 review