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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Spirulina vs Oxitard (antioxidant)

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Spirulina may leads to lower maximal mouth opening (interincisal distance) compared with oxitard (antioxidant) (low certainty).

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Depression · People with temporomandibular disorders (TMD)

Occlusal splint showed no clear difference in depression compared with physical therapy (ultrasound, exercise, sensorimotor training,…; GRADE not reported.

1 finding from 1 review

Orthodontic removable traction appliance (ORTA) vs no intervention

Overjet · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Orthodontic removable traction appliance (ORTA) led to higher overjet compared with untreated control (no treatment); GRADE not reported.

1 finding from 1 review

Superelastic NiTi arch wire vs Thermoelastic NiTi arch wire

Time to next/working arch wire · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Superelastic NiTi arch wire showed no clear difference in time to next/working arch wire compared with thermoelastic NiTi arch wire; GRADE not reported.

1 finding from 1 review

Used a pea-sized amount of fluoride toothpaste or less vs Used more than a pea-sized amount

Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years

It is very uncertain whether used a pea-sized amount of fluoride toothpaste or less changes fluorosis (percentage prevalence in permanent teeth) compared with used more than a pea-sized amount (very low certainty).

1 finding from 1 review

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

Pain at 24 hours · Adults with symptomatic apical periodontitis (no signs of spreading infection or systemic involvement)
1 finding from 1 review

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem traction bow, mandibular headgear, ORTA, reverse Twin Block, Reverse Forsus) vs no treatment

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Non-surgical orthodontic treatment (any: facemask, chin cup, tandem… led to higher wits appraisal compared with no treatment; GRADE not reported.

1 finding from 1 review

Intralesional steroid injections vs Alternative medicinal treatments

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injections showed no clear difference in maximal mouth opening (interincisal distance) compared with alternative medicinal treatments (low certainty).

2 findings from 1 review

Silver diamine fluoride (SDF) vs Sealants or resin infiltration

Primary caries prevention · Children and adults (with or without carious lesions)

The review found no eligible studies for this question.

3 findings from 1 review

Surgery plus Heister jaw opener vs Surgery plus wooden tongue depressors

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether surgery plus Heister jaw opener changes maximal mouth opening (interincisal distance) compared with surgery plus wooden tongue depressors (very low certainty).

2 findings from 1 review

Occlusal splint vs Another occlusal splint with a different mechanism of action

Frequency of joint noise · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes frequency of joint noise compared with another occlusal splint with a different mechanism of action (very low certainty).

1 finding from 1 review

Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics

Pain at 48 hours · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)

Postoperative systemic antibiotics… showed no clear difference in pain at 48 hours compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.

1 finding from 1 review

Occlusal splint vs Physical therapy (ultrasound, exercise, sensorimotor training, laser, TENS, manual therapy)

Severity of joint noise · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes severity of joint noise compared with physical therapy (ultrasound, exercise, sensorimotor training,… (very low certainty).

1 finding from 1 review

Facemask with rapid maxillary expansion (RME) vs Pushing Splints

Wits appraisal · Children and adolescents (aged 16 years or younger) with prominent lower front teeth (Class III malocclusion)

Facemask with rapid maxillary expansion (RME) showed no clear difference in wits appraisal compared with pushing Splints; GRADE not reported.

1 finding from 1 review

NiTi arch wire of one cross-sectional size vs NiTi arch wire of a different cross-sectional size

Pain · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
1 finding from 1 review
  • Different sizes of NiTi wires (Alhaija 2021; Erdinc 2004); not pooled due to clinical heterogeneity; little or no difference at day 1. Erdinc 0.014 vs 0.016 inch higher pain at day 4 MD 5.00 (0.19 to 9.81) and day 6 MD…
    2 studies · 149 participants
    Low

Occlusal splint vs Behavioural therapy (counselling, CBT, relaxation, self-care management)

Joint pain at rest · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes joint pain at rest compared with behavioural therapy (counselling, CBT, relaxation, self-care… (very low certainty).

1 finding from 1 review