Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

276 questions · 290 findings · 42 reviews · Headline outcomes only

No studies found 26 · 9%GRADE not reported 17 · 5.9%Very low 82 · 28.3%Low 92 · 31.7%Moderate 66 · 22.8%High 7 · 2.4%

Routine invasive strategies vs selective invasive strategies (conservative)

Fatal or nonfatal myocardial infarction · participants with UA/NSTEMI in the stent era

Routine invasive strategies showed no clear difference in death or non‐fatal Myocardial infarction compared with selective invasive strategies (conservative) (low certainty).

1 finding from 1 review

Routine invasive strategies vs selective invasive strategies (conservative)

Refractory angina · participants with UA/NSTEMI in the stent era

Routine invasive strategies probably leads to lower refractory angina compared with selective invasive strategies (conservative) (moderate certainty).

1 finding from 1 review

Routine invasive strategies vs selective invasive strategies (conservative)

Patient readmissions · participants with UA/NSTEMI in the stent era

Routine invasive strategies probably leads to lower rehospitalisation compared with selective invasive strategies (conservative) (moderate certainty).

1 finding from 1 review

Routine invasive strategies vs selective invasive strategies (conservative)

Complications of angiography or revascularization Bleeding · participants with UA/NSTEMI in the stent era

Routine invasive strategies probably leads to higher complications of angiography or revascularization Bleeding compared with selective invasive strategies (conservative) (moderate certainty).

1 finding from 1 review

Routine invasive strategies vs selective invasive strategies (conservative)

Complications of angiography or revascularization Procedure‐related myocardial infarction · participants with UA/NSTEMI in the stent era

Routine invasive strategies probably leads to higher complications of angiography or revascularization Procedure‐related… compared with selective invasive strategies (conservative) (moderate certainty).

1 finding from 1 review

Prophylactic vs selective blood transfusion

Severe maternal morbidity (congestive cardiac failure) · patients with sickle cell disease in pregnancy

It is very uncertain whether prophylactic changes severe maternal morbidity (congestive cardiac failure) compared with selective blood transfusion (very low certainty).

1 finding from 1 review

Intervention not reported

Incidence of a secondary primary breast cancer (e.g. in the contralateral breast) ‐ endocrine therapies not separated (exemestane (AI)/tamoxifen (SERM)/unknown) · women receiving endocrine therapy (selective oestrogen receptor modulator or aromatase inhibitor)
1 finding from 1 review