Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

949 questions · 1,008 findings · 130 reviews · Gynaecology and Fertility

No studies found 195 · 19.3%GRADE not reported 30 · 3%Very low 346 · 34.3%Low 323 · 32%Moderate 101 · 10%High 13 · 1.3%

Summary of findings table ‐ Progestogens vs GnRH antagonists

Live birth or ongoing pregnancy sensitivity analysis ‐ PCOS (high‐responders) ‐ own oocytes ‐ early phase stimulation protocol ‐ frozen embryo transfer (micronised progesterone 100 mg/day versus GnRH antagonists) · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in live birth or ongoing pregnancy sensitivity analysis ‐ PCOS… compared with gnRH antagonists; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Clinical pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in clinical pregnancy ‐ Poor‐responders (MPA 10 mg versus GnRH… compared with gnRH antagonists (low certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH agonist

Live birth or ongoing pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestagen showed no clear difference in live birth or ongoing pregnancy compared with gnRH agonist (low certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs Progestogen 2

Clinical pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestogen 1 showed no clear difference in clinical pregnancy ‐ Normo‐responders (MPA 10 mg versus… compared with progestogen 2 (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Live birth or ongoing pregnancy ‐ Poor‐responders (MPA 10 mg versus GnRH antagonists) ‐ Own oocytes ‐ Early phase stimulation protocol · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in live birth or ongoing pregnancy ‐ Poor‐responders (MPA 10 mg versus… compared with gnRH antagonists; GRADE not reported.

1 finding from 1 review

Intervention not reported

Live birth or ongoing pregnancy: early (EFP) vs late (LFP) follicular phase · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Clinical pregnancy: early (EFP) vs late (LFP) follicular phase (sensitivity analysis) · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)

It is very uncertain whether the intervention changes clinical pregnancy: early (EFP) vs late (LFP) follicular phase… (very low certainty).

1 finding from 1 review

Intentional endometrial injury vs no intervention or a sham procedure

Live birth or ongoing pregnancy · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)

It is very uncertain whether intentional endometrial injury changes live birth or ongoing pregnancy (sensitivity analysis) compared with no intervention or a sham procedure (very low certainty).

1 finding from 1 review

Intentional endometrial injury vs no intervention or a sham procedure

Clinical pregnancy · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)
2 findings from 1 review

Intervention not reported

Live birth or ongoing pregnancy: prior cycle vs IUI cycle · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Clinical pregnancy: prior cycle vs IUI cycle (sensitivity analysis) · infertile women or couples attempting to conceive through sexual intercourse or intrauterine insemination (IUI)

It is very uncertain whether the intervention changes clinical pregnancy: prior cycle vs IUI cycle (sensitivity analysis) (very low certainty).

1 finding from 1 review