Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

317 questions · 322 findings · 62 reviews · Eyes and Vision

No studies found 94 · 29.2%GRADE not reported 15 · 4.7%Very low 63 · 19.6%Low 91 · 28.3%Moderate 45 · 14%High 14 · 4.3%

Rituximab vs intravenous methylprednisolone

CAS improvement (decrease) by 2 or more points · thyroid‐associated ophthalmopathy

Summary of findings table ‐ Rituximab showed no clear difference in CAS improvement (decrease) by 2 or more points compared with intravenous methylprednisolone (low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

NOSPECS improvement (decrease) by 2 classes or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes NOSPECS improvement (decrease) by 2 or more classes compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Proptosis improvement (decrease) by 2 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes proptosis improvement (decrease) by 2 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Palpebral aperture improvement (decrease) by 3 mm or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes palpebral aperture improvement (decrease) by 3 mm or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Rituximab vs intravenous methylprednisolone

Motility improvement (increase) by 1 class or more · thyroid‐associated ophthalmopathy

It is very uncertain whether summary of findings table ‐ Rituximab changes motility improvement (increase) by 1 class or more compared with intravenous methylprednisolone (very low certainty).

1 finding from 1 review

Intervention not reported

Additional medications required · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Complications · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Further surgical or laser interventions · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Quality of life measures · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Disease progressionAssessed by: dilated assessment of the vertical C/D ratio using a 78 D lens · adults with PAC or PACG, and previous PI
1 finding from 1 review

Intervention not reported

Further surgical or laser interventions · adults with PAC or PACG, and previous PI
1 finding from 1 review

Intervention not reported

Quality of life measures · adults with PAC or PACG, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Disease progression · adults with PACS or PAC, and previous PI

The review found no eligible studies for this question.

1 finding from 1 review