Proportion of children who had sedation failure after 1 dose of sedative agent · children undergoing neurodiagnostic procedures
Chloral hydrate oral (100 mg/kg or 75 mg/kg) showed no clear difference in proportion of children who had sedation failure after 1 dose of… compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (low certainty).
1 finding from 1 review
Sedation duration (minutes) · children undergoing neurodiagnostic procedures
1 finding from 1 review
Proportion of children who required a further dose of either the same sedative agent or the addition of a different sedative agent · children undergoing neurodiagnostic procedures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
EEG sedative‐induced artefact · children undergoing neurodiagnostic procedures
Chloral hydrate oral (100 mg/kg or 75 mg/kg) leads to lower EEG sedative‐induced artefact compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (high certainty).
1 finding from 1 review
Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures
Chloral hydrate oral (100 mg/kg or 75 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (low certainty).
1 finding from 1 review
Time to adequate sedation (minutes or as measured by specific validated scales such as the Ramsay Sedation Score) · children undergoing neurodiagnostic procedures
1 finding from 1 review
Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures
Chloral hydrate oral (50 mg/kg or 100 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (moderate certainty).
1 finding from 1 review
Sedation duration (minutes) · children undergoing neurodiagnostic procedures
1 finding from 1 review
Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures
Chloral hydrate oral (50 mg/kg or 100 mg/kg) may leads to higher number of children with clinical adverse events (any) compared with dexmedetomidine oral (2 µg/kg or 3 µg/kg) (low certainty).
1 finding from 1 review
Frequency of leg cramps after treatment: never · treating leg cramps in pregnancy
It is very uncertain whether oral calcium changes frequency of leg cramps after treatment: never compared with oral vitamin C (very low certainty).
1 finding from 1 review
Recurrent VTE · participants with diagnosed DVT
Oral DTIs showed no clear difference in recurrent VTE (7 months) compared with conventional anticoagulation (moderate certainty).
1 finding from 1 review
Recurrent DVT (3 to 12 months) · participants with diagnosed DVT
Oral DTIs showed no clear difference in recurrent DVT (7 months) compared with conventional anticoagulation (moderate certainty).
1 finding from 1 review
Fatal PE (3 to 12 months) · participants with diagnosed DVT
Oral DTIs showed no clear difference in fatal PE (7 months) compared with conventional anticoagulation (moderate certainty).
1 finding from 1 review
Non‐fatal PE (3 to 12 months) · participants with diagnosed DVT
Oral DTIs showed no clear difference in non‐fatal PE (7 months) compared with conventional anticoagulation (moderate certainty).
1 finding from 1 review
All‐cause mortality (7 months) · participants with diagnosed DVT
Oral DTIs showed no clear difference in all‐cause mortality (7 months) compared with conventional anticoagulation (moderate certainty).
1 finding from 1 review
Major bleeding · participants with diagnosed DVT
Oral DTIs leads to lower major bleeding (7 months) compared with conventional anticoagulation (high certainty).
1 finding from 1 review
Subgroup · children in malaria‐endemic areas
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Clinical malaria · children in malaria‐endemic areas
Oral iron showed no clear difference in clinical malaria compared with placebo or no treatment (high certainty).
1 finding from 1 review
Clinical malaria Subgrouped by population anaemia (trial level) · children in malaria‐endemic areas
Oral iron showed no clear difference in clinical malaria Subgrouped by population anaemia (trial level) compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Severe malaria · children in malaria‐endemic areas
Oral iron leads to lower severe malaria Defined as clinical malaria with high‐grade… compared with placebo or no treatment (high certainty).
1 finding from 1 review