Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

159 questions · 167 findings · 16 reviews

No studies found 28 · 16.8%GRADE not reported 2 · 1.2%Very low 38 · 22.8%Low 53 · 31.7%Moderate 27 · 16.2%High 19 · 11.4%

Intervention not reported

Cognition: BSID II score at < 24 months · children of women randomised to omega‐3 or no omega‐3 during pregnancy

The intervention showed no clear difference in cognition: BSID II score at < 24 months (low certainty).

1 finding from 1 review

Intervention not reported

Cognition: BSID III score at < 24 months · children of women randomised to omega‐3 or no omega‐3 during pregnancy

The intervention showed no clear difference in cognition: BSID III score at < 24 months (low certainty).

1 finding from 1 review

Intervention not reported

IQ: WASI at 7 years · children of women randomised to omega‐3 or no omega‐3 during pregnancy

The intervention showed no clear difference in IQ: WASI at 7 years (low certainty).

1 finding from 1 review

Intervention not reported

IQ: WISC‐IV at 12 years · children of women randomised to omega‐3 or no omega‐3 during pregnancy

It is very uncertain whether the intervention changes IQ: WISC‐IV at 12 years (very low certainty).

1 finding from 1 review

Intervention not reported

Behaviour: BSID III adaptive behaviour score at 12‐18 months · children of women randomised to omega‐3 or no omega‐3 during pregnancy

The intervention showed no clear difference in behaviour: BSID III adaptive behaviour score at 12‐18 months (low certainty).

1 finding from 1 review

Intervention not reported

Behaviour: SDQ Total Difficulties at 7 years · children of women randomised to omega‐3 or no omega‐3 during pregnancy

The intervention may leads to higher behaviour: SDQ Total Difficulties at 7 years (low certainty).

1 finding from 1 review

Intervention not reported

BMI at 19 years · children of women randomised to omega‐3 or no omega‐3 during pregnancy

It is very uncertain whether the intervention changes BMI at 19 years (very low certainty).

1 finding from 1 review

Intervention not reported

Diabetes · children of women randomised to omega‐3 or no omega‐3 during pregnancy

The review found no eligible studies for this question.

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (continuous) HDRS where possible; higher scores indicate greater symptomology · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Adverse events Study reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes adverse eventsStudy reports compared with placebo (very low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ remission) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ remission)Depressive… compared with placebo (low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ response) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ response)Depressive… compared with placebo (low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Quality of lifeValidated quality of life scales as used by authors, CGI (7‐point scale) where possible, higher scores indicate poorer quality of life · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Trial non‐completionStudy reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes trial non‐completionStudy reports compared with placebo (very low certainty).

1 finding from 1 review