Findings

What do systematic reviews say?

136 questions · 140 findings · 17 reviews · Vascular

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No studies found 22 · 15.7%GRADE not reported 13 · 9.3%Very low 28 · 20%Low 50 · 35.7%Moderate 18 · 12.9%High 9 · 6.4%

Intervention not reported

Amputation · Individuals with peripheral arterial disease

The intervention showed no clear difference in amputation (high certainty).

1 finding from 1 review

Bypass surgery for chronic lower limb ischaemia 2017 · Cochrane Headline outcomes only
OR 1.24 [0.82, 1.87]
5 studies · 752 participants
High

Intervention not reported

Primary patency · Individuals with peripheral arterial disease

The intervention probably leads to higher primary patency (moderate certainty).

1 finding from 1 review

Bypass surgery for chronic lower limb ischaemia 2017 · Cochrane Headline outcomes only
OR 1.94 [1.2, 3.14]
4 studies · 300 participants
Moderate

Intervention not reported

Primary patency · Individuals with peripheral arterial disease

The intervention showed no clear difference in primary patency (high certainty).

1 finding from 1 review

Bypass surgery for chronic lower limb ischaemia 2017 · Cochrane Headline outcomes only
OR 1.15 [0.74, 1.78]
2 studies · 363 participants
High

Intervention not reported

Mortality within · Individuals with peripheral arterial disease

The intervention showed no clear difference in mortality within (high certainty).

1 finding from 1 review

Bypass surgery for chronic lower limb ischaemia 2017 · Cochrane Headline outcomes only
OR 0.94 [0.71, 1.25]
5 studies · 961 participants
High

Subintimal angioplasty with stenting vs remote endarterectomy

Clinical improvement: Rutherford classification improvement Rutherford classification · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in clinical improvement: Rutherford classification improvement… compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.79 [0.61, 1.03]
1 study · 95 participants
Low

OUTBACK re‐entry catheter vs manual re‐entry

Technical success · 52 people with TASC‐II D superficial femoral artery chronic total occlusions

OUTBACK re‐entry catheter showed no clear difference in technical success rate compared with manual re‐entry (low certainty).

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 1 [0.93, 1.08]
1 study · 52 participants
Low

OUTBACK re‐entry catheter vs manual re‐entry

months' patency rate · 52 people with TASC‐II D superficial femoral artery chronic total occlusions

OUTBACK re‐entry catheter showed no clear difference in months' patency rate compared with manual re‐entry (low certainty).

2 findings from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 1.04 [0.94, 1.15]
1 study · 52 participants
Low
Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 1.09 [0.9, 1.33]
1 study · 52 participants
Low

OUTBACK re‐entry catheter vs manual re‐entry

Primary patency ( · 52 people with TASC‐II D superficial femoral artery chronic total occlusions

2 findings from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
GRADE not reported
Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
GRADE not reported

OUTBACK re‐entry catheter vs manual re‐entry

Limb salvage · 52 people with TASC‐II D superficial femoral artery chronic total occlusions

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
GRADE not reported

OUTBACK re‐entry catheter vs manual re‐entry

Complications · 52 people with TASC‐II D superficial femoral artery chronic total occlusions

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Low

Subintimal angioplasty with stenting vs remote endarterectomy

Clinical improvement: ABI improvement Significant postexercise ABI improvement · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in clinical improvement: ABI improvement Significant postexercise ABI… compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.86 [0.68, 1.08]
1 study · 95 participants
Low

Subintimal angioplasty with stenting vs remote endarterectomy

Technical success · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in technical success rate compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.97 [0.88, 1.07]
1 study · 95 participants
Low

Subintimal angioplasty with stenting vs remote endarterectomy

months' patency rate · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in months' patency rate compared with remote endarterectomy (low certainty).

3 findings from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.75 [0.57, 1]
1 study · 95 participants
Low
Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.74 [0.55, 1]
1 study · 95 participants
Low
Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.76 [0.52, 1.11]
1 study · 95 participants
Low

Subintimal angioplasty with stenting vs remote endarterectomy

Limb salvage · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in months' limb salvage rate compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.97 [0.9, 1.05]
1 study · 95 participants
Low

Subintimal angioplasty with stenting vs remote endarterectomy

Complications · 95 people with Rutherford 3 to 5 TASC‐II D lesions

Subintimal angioplasty with stenting showed no clear difference in complications compared with remote endarterectomy (low certainty).

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
RR 0.77 [0.14, 4.42]
1 study · 95 participants
Low

OUTBACK re‐entry catheter vs manual re‐entry

Clinical improvement · 52 people with TASC‐II D superficial femoral artery chronic total occlusions

1 finding from 1 review

Subintimal angioplasty for lower limb arterial chronic total occlusions 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
GRADE not reported