Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

516 questions · 950 findings · 74 reviews · Dental caries

No studies found 35 · 3.7%GRADE not reported 831 · 87.5%Very low 38 · 4%Low 26 · 2.7%Moderate 13 · 1.4%High 7 · 0.7%

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Tooth staining/discolouration (adverse effect) · Children and adolescents aged 16 years or less
1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Dental caries · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

The review found no eligible studies for this question.

2 findings from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Mother self-reported oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Mother plaque (sub- and supragingival calculus) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

Dietary advice on how to achieve a healthy diet for infants… showed no clear difference in mother plaque (sub- and supragingival calculus) compared with standard care; GRADE not reported.

1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Mother gingival health (mild or moderate bone loss) · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

Dietary advice on how to achieve a healthy diet for infants… showed no clear difference in mother gingival health (mild or moderate bone loss) compared with standard care; GRADE not reported.

1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Child oral health behaviours · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…
1 finding from 1 review

Dietary advice on how to achieve a healthy diet for infants (tailored advice focused on a diet low in saturated fat and cholesterol intake) vs usual care

Caries presence in primary teeth · For interventions, pregnant women, mothers or other caregivers of infants in the first year of life; for outcomes, children up to 6 years…

It is very uncertain whether dietary advice on how to achieve a healthy diet for infants… changes caries presence in primary teeth compared with standard care (very low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Postoperative hypersensitivity (POH), patient-reported (dichotomous yes/no) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Dental cavity liner (e.g. calcium hydroxide, glass ionomer,… showed no clear difference in postoperative hypersensitivity (POH), patient-reported (dichotomous… compared with no liner (resin-based composite bonded directly to the tooth) (low certainty).

3 findings from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Postoperative hypersensitivity (POH), cold response measurement (time in seconds) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Dental cavity liner (e.g. calcium hydroxide, glass ionomer,… may leads to higher postoperative hypersensitivity (POH), cold response measurement… compared with no liner (resin-based composite bonded directly to the tooth) (low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Restoration failure · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth
2 findings from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Cost of materials · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth
1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Postoperative hypersensitivity (POH), cold response measurement (VAS score) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Dental cavity liner (e.g. calcium hydroxide, glass ionomer,… showed no clear difference in postoperative hypersensitivity (POH), cold response measurement (VAS… compared with no liner (resin-based composite bonded directly to the tooth); GRADE not reported.

2 findings from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Postoperative hypersensitivity (POH), patient-reported (VAS score) · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

Dental cavity liner (e.g. calcium hydroxide, glass ionomer,… led to lower postoperative hypersensitivity (POH), patient-reported (VAS score) compared with no liner (resin-based composite bonded directly to the tooth); GRADE not reported.

2 findings from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No liner (resin-based composite bonded directly to the tooth)

Adverse events · Adults or children with a Class I or Class II resin-based composite restoration in a permanent posterior tooth

The review found no eligible studies for this question.

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Restoration longevity · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

Cavity liners may make little or no difference to restoration longevity (high success across groups; low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Treatment failure · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

The evidence is very uncertain about the effect of cavity liners on treatment failure; no significant difference between lined and unlined (or differently lined) restorations was found (very low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Postoperative hypersensitivity (POH), patient-reported (VAS score) · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

The evidence is very uncertain whether cavity liners reduce postoperative hypersensitivity; no significant difference was found overall (very low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Tooth survival · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

Cavity liners may make little or no difference to tooth survival (99.4% survival across groups; low certainty).

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Oral health-related quality of life · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

No included study reported oral health-related quality of life (a planned outcome), so no evidence is available.

1 finding from 1 review

Dental cavity liner (e.g. calcium hydroxide, glass ionomer, resin-modified glass ionomer, or flowable composite) placed under the restoration vs No cavity liner or a different liner material

Secondary prevention of caries · Patients with deep caries lesions in mature or immature permanent (posterior) teeth, with no symptoms or reversible pulpitis

Cavity liners may make little or no difference to secondary caries prevention (~100% prevention across groups; low certainty).

1 finding from 1 review