What do systematic reviews say?

Loratadine 10 mg vs desloratadine 5 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with desloratadine 5 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.64, 1.71]
  3 studies · 410 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

It is very uncertain whether loratadine 10 mg changes complete cessation of urticaria: intermediate‐term duration of… compared with mizolastine 10 mg (very low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.86 [0.64, 1.16]
  3 studies · 316 participants
  Very low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.88 [0.55, 1.42]
  3 studies · 314 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

Loratadine 10 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with mizolastine 10 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 0.38 [0.04, 3.6]
  2 studies · 267 participants
  Low

Loratadine 10 mg vs mizolastine 10 mg

It is very uncertain whether loratadine 10 mg changes proportion of participants with at least 50% improvement in QoL:… compared with mizolastine 10 mg (very low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 3.21 [0.32, 32.33]
  2 studies · 252 participants
  Very low

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in complete cessation of urticaria: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.04 [0.78, 1.39]
  1 study · 161 participants
  Moderate

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.09 [0.96, 1.24]
  1 study · 160 participants
  Moderate

Loratadine 10 mg vs emedastine 2 mg

Loratadine 10 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.09 [0.07, 17.14]
  1 study · 161 participants
  Moderate

Loratadine 10 mg vs hydroxyzine 25 mg

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: short‐term duration of… compared with hydroxyzine 25 mg (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1 [0.32, 3.1]
  1 study · 12 participants
  Low

Hydroxyzine 25 mg vs placebo

Hydroxyzine 25 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 3.64 [0.77, 17.23]
  2 studies · 270 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Low

Desloratadine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Low

Desloratadine 5 to 20 mg vs placebo

Desloratadine 5 to 20 mg showed no clear difference in adverse effects leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  RR 1.46 [0.42, 5.1]
  3 studies · 466 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Levocetirizine 5 to 20 mg vs placebo

• H1‐antihistamines for chronic spontaneous urticaria 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 49 participants
  Low

Tonsillectomy vs no intervention

The review found no eligible studies for this question.

• Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Tonsillectomy vs no intervention

It is very uncertain whether tonsillectomy changes proportion of participants with adverse events and severe adverse… compared with no intervention (very low certainty).

• Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
  RR 2.81 [0.12, 63.83]
  1 study · 29 participants
  Very low

Tonsillectomy vs no intervention

It is very uncertain whether tonsillectomy changes proportion of participants achieving clear or almost clear skin… compared with no intervention (very low certainty).

• Antistreptococcal interventions for guttate and chronic plaque psoriasis 2019 · Cochrane Headline outcomes only
  RR 2.81 [0.12, 63.83]
  1 study · 29 participants
  Very low