What do systematic reviews say?

Pyridoxine vs placebo

Pyridoxine showed no clear difference in interventions side effects: palpitations compared with placebo (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 1 [0.22, 4.6]
  1 study · 66 participants
  Low

Pyridoxine vs placebo

Pyridoxine showed no clear difference in interventions side effects: dry mouth compared with placebo (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.82 [0.49, 1.38]
  1 study · 66 participants
  Low

Metoclopramide vs ondansetron

Metoclopramide probably leads to higher intervention side effects: felt drowsy compared with ondansetron (moderate certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 2.4 [1.23, 4.69]
  1 study · 160 participants
  Moderate

Metoclopramide vs ondansetron

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with ondansetron (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 1.29 [0.5, 3.28]
  1 study · 160 participants
  Low

Metoclopramide vs ondansetron

Metoclopramide probably leads to higher intervention side effects: dry mouth compared with ondansetron (moderate certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 2.38 [1.1, 5.11]
  1 study · 160 participants
  Moderate

Metoclopramide vs ondansetron

Metoclopramide showed no clear difference in intervention side effects: felt dizzy compared with ondansetron (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 2.33 [0.94, 5.77]
  1 study · 160 participants
  Low

Metoclopramide vs promethazine

Metoclopramide probably leads to lower intervention side effects: drowsy compared with promethazine (moderate certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.7 [0.56, 0.87]
  1 study · 143 participants
  Moderate

Metoclopramide vs promethazine

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with promethazine (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.78 [0.4, 1.53]
  1 study · 143 participants
  Low

Metoclopramide vs promethazine

Metoclopramide showed no clear difference in intervention side effects: dry mouth compared with promethazine (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.91 [0.62, 1.34]
  1 study · 143 participants
  Low

Metoclopramide vs promethazine

Metoclopramide probably leads to lower intervention side effects: felt dizzy compared with promethazine (moderate certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.48 [0.34, 0.69]
  1 study · 143 participants
  Moderate

Metoclopramide vs promethazine

Metoclopramide showed no clear difference in intervention side effects: diarrhea compared with promethazine (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 1.39 [0.32, 5.99]
  1 study · 143 participants
  Low

Metoclopramide vs promethazine

Metoclopramide showed no clear difference in intervention side effects: headache compared with promethazine (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.81 [0.47, 1.38]
  1 study · 143 participants
  Low

Ondansetron vs promethazine

Ondansetron may leads to lower intervention side effect: sedation compared with promethazine (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.06 [0, 0.94]
  1 study · 30 participants
  Low

Corticosteroids vs promethazine

Corticosteroids showed no clear difference in intervention side effects: drowsiness 48hrs and 3‐10 days compared with promethazine (low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.08 [0, 1.32]
  1 study · 80 participants
  Low

Corticosteroids vs placebo

It is very uncertain whether corticosteroids changes intervention side effects compared with placebo (very low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 0.79 [0.06, 11.2]
  1 study · 25 participants
  Very low

Acupuncture vs placebo

The review found no eligible studies for this question.

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Acupuncture vs metoclopramide

The review found no eligible studies for this question.

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cervical pessary vs vaginal progesterone

• Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 11 participants
  Low

Cervical pessary vs cervical cerclage

• Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 13 participants
  Low

Cervical pessary vs no treatment

The review found no eligible studies for this question.

• Cervical pessary for preventing preterm birth in singleton pregnancies 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found